Báo cáo khoa học: Mechanism of the reaction catalyzed by dehydroascorbate reductase from spinach chloroplasts doc

... point of intervention within the biosynthetic pathway of ADAM10 is provided by directly interfer- ing with the expression of the gene for ADAM10: the promoter region of the gene for ADAM10 has been characterized ... treatment of AD, enhance the transport of ADAM10 to the cell surface and the non-amylodogenic cleavage of APP [91,92]. ADAM10 has also been shown t...

Ngày tải lên: 16/02/2014, 09:20

... intermediate by the unique action of the serpin, whereby the RCL of the serpin inserts into the major A b -sheet causing the protease to be rapidly translo- cated from the top to the bottom of the inhibitor ... polymers of serpins, where the insertion of another molecule’s RCL takes place [8]. Both of these result in the irreversible inactivation (general...

Ngày tải lên: 20/02/2014, 02:21

... activating the nucleophilic water m olecule) in the first step of the reaction. A carbonium ion intermediate subsequently forms, and is further attacked by the water molecule. The study of site-directed ... were used. The protein concentration was measured by the method of Lowry et al. with B SA as standard [37]. TLC TLC was p erformed to analyse t he hydrolysates of...

Ngày tải lên: 19/02/2014, 16:20

... Epimerization results from the re-formation of the C–C bond after the reorientation of glycolaldehyde, which exposes the opposite face of the aldehyde. The mechanism of the epimerization reaction is very ... performed in the absence of the ligand. The control data set obtained in the absence of the ligand was subtrac- ted from the corresponding da...

Ngày tải lên: 19/02/2014, 00:20

... that the swollen envelope is formed as filaments by the assembly of ZP domains, and cleavage of the LCE site at the center of the ZP domain con- tributes to the complete solubilization of the HCE- swollen ... regions of the hardened egg envelope, leading to the release of small fragments from the envelope, and swelling or loosening of the compact structu...

Ngày tải lên: 06/03/2014, 02:20

... suffered at least loss of one rel- ative, for example, a partner or child, and two mothers of our cohort lost both of their children. The majority of patients com- plained of nightmares, emotional ... aftermath With respect to the tsunami's psychoemotional aftermath, the full impact of the wave on the mental health of the survivors is still unknown [2]. In Febru...

Ngày tải lên: 25/10/2012, 10:41

... as the ATP-unbound and Ca 2+ -bound E1Ca 2+ form. In the histogram (Fig. 2A) of the dis- tribution of the height of the projection of the embed- ded molecule above the flat membrane surface, the average ... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy- ses of SERCA were performed...

Ngày tải lên: 14/02/2014, 14:20

... 1B shows the pattern seen after the development of the blot. With increase in time of incubation, the intensity of the band for the monomeric protein decreased, whereas the bands for the higher ... Nota- bly, in the presence of the neurotoxin, there was a delay in the lag time for fibrillation. The lag time increased from 74.9 h in case of a -synuclein alone...

Ngày tải lên: 14/02/2014, 19:20

... length restrictions of this minireview. The work of S.W. was supported by the Deutsche Forschungsgemeinschaft (We2843 ⁄ 2-1) and BGAG-Stiftung Walter Hesselbach. The work of S.B. is supported by grants from the ... followed by T-pilus assembly. The assem- bled T4SS then triggers the secretion of substrates from the bacterial cytoplasm directly into the cytopl...

Ngày tải lên: 14/02/2014, 19:20

... preferentially the phosphorylation of the p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms. To confirm functional activation of the JNK signaling ... efforts were frustrated by the lack of specificity of SP600125, which has also been reported by others [42,43]. Resolution of the importance of JNK activa- tion...

Ngày tải lên: 16/02/2014, 14:20