Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc

... Biochem. 270) Ó FEBS 2003 Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage M. Fleur Sernee 1 , ... & Allsop, D. ( 199 9) Alzheimer’s disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with i...

Ngày tải lên: 08/03/2014, 08:20

... AR-JP, and 77% of sporadic cases with disease onset before the age of 20 [2]. Clinically, PD patients with mutations in PARK2 suffer a slow progression of the disease commonly associated with early-onset ... MM (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci USA 102, 96 91 96 96. 29 She...

Ngày tải lên: 18/02/2014, 14:20

... Department of Molecular Neuroscience, Institute of Neurology, University College London, UK 5 Reta Lila Weston Institute and Department of Neurodegenerative Disease, Institute of Neurology, London, ... is the major component of Lewy bodies and mutations in this gene are a rare cause of PD. Only three point mutations have been described to date, but duplication and triplicat...

Ngày tải lên: 18/02/2014, 14:20

Ngày tải lên: 09/03/2014, 01:20

... minor conformation of APV showed one less hydrogen bond, one less C-HÆÆÆO interaction and weaker interactions than the major conformation had with PR. Effects of mutations on PR structure and interactions ... oxygen and the carbamate car- bonyl oxygen of APV. The second conserved water (H 2 O B ) bridged APV and the PR main chain by hydrogen bonds to the carbonyl of Gly27...

Ngày tải lên: 18/02/2014, 04:20

... hydroxylation of mono- phenols and the oxidation of o-diphenols. Different names are used for these activit- ies, as shown in the Figure. One of the most common monophenolic substrates is tyrosine, and ... as a function of the concentration of l-dopa cofactor added to the assay mixture. R3-1501 – extracts have a high TH activity, almost independent of the addition of l-do...

Ngày tải lên: 19/02/2014, 07:20

... fragment population(x 1 ) on the left and sub-string “popula- tion of q.x 1 ” on the right. Variable x 1 stands for an MR subtree under population, and, on the right, state-variable pair q.x 1 stands for ... left hand side of rule r and u its right hand side. The transducer is linear iff no vari- able appears more than once on the right hand side. It is non-deleting iff all v...

Ngày tải lên: 19/02/2014, 19:20

... F-measure AER GIZA++ standard 0 .92 5 0. 791 0.853 0.136 with SRH 0 .93 4 0.803 0.864 0.126 HM-BiTAM standard 0. 898 0.851 0.874 0.124 with SRH 0 .90 9 0.860 0.8 79 0.114 Proposed 0 .92 7 0.862 0. 893 0.103 (c) Table ... standard 0 .90 5 0.770 0.832 0.156 with SRH 0 .90 3 0.7 59 0.825 0.164 HM-BiTAM standard 0 .90 1 0.814 0.855 0.140 with SRH 0. 899 0.808 0.853 0.145 Proposed 0 .94...

Ngày tải lên: 20/02/2014, 04:20

... Definition. In Proceedings of the Sixth Message Understanding Conference (MUC- 6). MUC-7. 199 7. Coreference Task Definition. In Proceed- ings of the Seventh Message Understanding Conference (MUC-7). V. ... implementation of the Lappin and Leass’ ( 199 4) Resolution of Anaphora Procedure (RAP). JavaRap resolves only pronouns and, thus, it is not directly comparable to Reconcile. GuiT...

Ngày tải lên: 20/02/2014, 04:20

... 1188 11 89 Proceedings of the 49th Annual Meeting of the Association for Computational Linguistics, pages 11 79 11 89, Portland, Oregon, June 19- 24, 2011. c 2011 Association for Computational Linguistics 11 79 1180 1181 1182 1183 1184 1185 1186 ... 11 79 11 89, Portland, Oregon, June 19- 24, 2011. c 2011 Association for Computational Linguistics 11 79 1180 1181 1182 1183 1184 118...

Ngày tải lên: 20/02/2014, 04:20