Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... strong, neutralizing action of the cytosolic RNaseinhibitor (cRI), a 50-kDa protein containing 16 leu-cine-rich repeat motifs [7,8]. In fact, onconase fromRana pipiens eggs [9], and seminal RNase ... of EIE were recorded at 30° inter-vals of r from 0 to 360°;(d) the inclination of the dimer major axis with respect tothe z axis, hence to the membrane plane, was changed (byinclination of ... determining the inter-mixing of DMPG phospholipids between unlabeledvesicles and vesicles labeled with a donor ⁄ acceptor pair of ﬂuorescent probes. When the RNase under test pro-moted intermixing,...

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

... evidence thatN-glycans, in particular their terminal structures, areinvolved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA.Transport of GABA by GAT1 across ... that N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of theterminal ... 1-deoxymannojirimycin (dMM). Thisindicates that N-glycosylation, but not terminal trimming of the N-glycansis involved in the attainment of a correctly folded and stable conformation of GAT1. All...

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... suggesting that downregulation of miR-27 is not sufﬁcient to promote adipogenesis.We performed a time course study to gain furtherinsights into the role of miR-27 during different stages of adipogenesis ... and speciﬁc role of miR-27 in the regulation of adipogenic differentiation.miR-27 prevents the induction of PPARc andC⁄EBPa In order to delineate the mechanisms by which miR-27inhibits adipogenic ... notrepress the level of PPARc protein in committed prea-dipocytes under physiologically relevant conditions.Expression of miR-27 is elevated in obese mice In order to gain insights into the potential...

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... Quercetindid not inhibit ROS generation, and enhanced cytotoxicity of Topotecan in both cells. In contrast, NAC enhanced resistanceagainst doxorubicine and vincristine in MRP1 overexpressingcells. ... perplexing diversity of lesions is continuously induced in our genes ranging from sin-gle and double strand breaks, to chemical alterations of nucleo-tides including adducts, as well as inter- ... activation of JNK, serineAbstracts19phosphorylation of insulin receptor substrate 1 (IRS1), andinhibition of insulin action. Hence, we conclude that JNK acti-vation and ER stress, integrates in ammatory...

Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

... that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... thebovine complex a large subdomain is made up of  20integral membrane proteins contributing > 60 transmem-brane segments. Some of these must be intimately involved in proton pumping. Another ... proteins reveals a high degree of conservation in the C-terminal domain (including thetransmembrane region), but a signiﬁcant number of differ-ences in the N-terminal domain (located on the matrix...

Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

... (sea-urchin sperm protein, enterokinase and agrin) –modulecleavage, association of fragments and membrane tar-geting of rat intestinal mucin Muc3. Biochem J 372,263–270.12 Maeda T, Inoue M, ... according to the intensity of M2-reactivespecies in the corresponding whole cell lysate.Molecular modeling of SEA domain of MUC1The composer and biopolymer modules of the sybyl 6.91software package ... and mucin cleavageFEBS Journal 272 (2005) 2901–2911 ª 2005 FEBS 2911The role of the SEA (sea urchin sperm protein,enterokinase and agrin) module in cleavage of membrane-tethered mucinsTimea...

Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf

... The Role Of Focussing in Interpretation of Pronouns Candace L. Sidner Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge, MA ... authors all point out the need for inferencing as part of anaphora disambiguation, but each of their schemes for inferencing suffer from the need for control which will reduce the combinatorial ... represented in a database. Using this framework, the paper supports two claims by means of rules for antecedence. I. The focus provides a source of antecedence in rules for interpreting pronominal...

Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf

... Rules for Assigning Initiativeabout the effectiveness of Socratic tutoring in theBEE domain or Socratic tutoring in general.3.2 Initiative Annotation MethodThe two definitions of initiative we ... an-notated using changes in initiative as a starting point; thesechanges were taken as marking either a segment endpoint orthe beginning of a nested segment.tion following a question takes initiative. ... sharing of initiative — the expert had ini-tiative for 60% of the turns in finance ADs and51% of the turns in software ADs. This is because in the ADs, the novice must communicate the de-tails of...

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... value determined from the amino acidsequence (45 320 Da).Measurement of the Kd of PLP bindingequilibriumPLP binding equilibria were analyzed taking advantage of the protein intrinsic ﬂuorescence ... arelocated in the cores of the large and small domains,respectively, and appear to stabilize their protein scaf-folds, allowing the proper positioning of the residuesinvolved in PLP binding, substrate ... quenching observed uponthe binding event [10]. Dissociation constants of bindingequilibria were then calculated from saturation curvesobtained measuring the protein ﬂuorescence emission inten-sity...

Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding afﬁnity pptx

... binders by repeated pannings, we adopteda combination of a round of biopanning and subse-quent screening of functional Fv by ELISA. A mini-mum round of panning would allow selection of binders ... antigen-binding afﬁnityand the VH⁄ VLinteraction strength determined, ﬁveclones in the H39Q group showed both high antigen-binding afﬁnity and strong VH⁄ VLinteraction. In Table 1. Result of ... clearwhether or not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect of the H39 mutation on antigenbinding has not yet been analyzed....

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