... preventing the formation of a noncleavable procathepsin B mutant.Next, we evaluated the activity of the mature formsresulting from the processing of procathepsin Bmutants. All these forms of cathepsin ... inhibitory role of the propep-tide, although the active site is already formed andcapable of hydrolyzing the substrates.Autocatalytic processing of procathepsin Bis delayed in the presence of small ... Biology Core, Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco,CA, USA4 Department of Pathology, Stanford University School of Medicine, CA, USACysteine...