... preventing the formation of a noncleavable procathepsin B mutant. Next, we evaluated the activity of the mature forms resulting from the processing of procathepsin B mutants. All these forms of cathepsin ... inhibitory role of the propep- tide, although the active site is already formed and capable of hydrolyzing the substrates. Autocatalytic processing of procathepsin B is...
Ngày tải lên: 07/03/2014, 03:20
... semantic information. The collocation for ambiguous words also contains semantic information about multiple senses for this ambiguous word. This paper uses the ambiguity of collocation for the ... of the central word is ordered according to word senses. Figure 1 show the overall process for this purpose. Figure 1 Processing for detecting sense boundary 3 Automatic...
Ngày tải lên: 20/02/2014, 16:20
Tài liệu Báo cáo khoa học: "A SPEECH-FIRST MODEL FOR REPAIR DETECTION AND CORRECTION" docx
... detection of repairs in recognition, permitting early pruning of the hypothesis space. One proposal for repair processing that lends it- self to both incremental processing and the integration of ... 9% 3 1 0.3% Table 2: Length of Reparandum Offset Word Frag- ments (N=288) bution of initial phonemes for all words in the corpus of 6,414 ATIS sentences, and for all...
Ngày tải lên: 20/02/2014, 21:20
Tài liệu Báo cáo khoa học: "Syntactic and Semantic Kernels for Short Text Pair Categorization" docx
... a new kernel for the repre- sentation of shallow semantic information along with a comprehensive study on ker- nel methods for the exploitation of syntac- tic/semantic structures for short text ... 2.1) for which efficient algorithms have been devel- oped. Once a sequence of arguments is output by SK, for each argument, we account for the poten- tial matches of its children...
Ngày tải lên: 22/02/2014, 02:20
Báo cáo khoa học: "An Efficient Indexer for Large N-Gram Corpora" docx
... basic language model. 1 Introduction The goal of statistical language modeling is to cap- ture the properties of a language through a proba- bility distribution so that the probabilities of word sequences ... of sequences of words (N-grams) and their associated counts extracted from a Web corpus of approximately one trillion words. The length of each sequence, N, ranges fr...
Ngày tải lên: 07/03/2014, 22:20
Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... pointed to a role for components of the ER–Golgi vesicle transport. Through the use of mark- ers for the ER (PDI) and the Golgi apparatus (GM130, p230), the phosphorylated isoforms of the K650M mutant ... cells were transfected for 48 h, the relative level of the 105 kDa isoform was slightly reduced (Fig. 1A). Transient expression of the X807R mutation gave rise to three isofo...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... responsible for the processing of IGFBP-rP1. Results Expression and processing of IGFBP-rP1 in various cell lines We have reported that IGFBP-rP1 is proteolytically converted to a two-chain form during ... the presence of 10 mm CaCl 2 , as described in Experimental procedures. Of the nine cell lines tested, OVISE, Fig. 1. Analysis of noncleaved and cleaved forms of IGFBP-rP1...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: "The Use of Ooject-Special Knowledge in Natural Language Processing" doc
... memory this OF description of what it means For a bottle to be open. This information is stored Peneath its prototype For bottles. Presumably, there Is also script-like information about ... the different methods For opening bottles, the different types of caps (corks, twist-off, ), and which method is appropriate For which cap. However, For the purpose of underst...
Ngày tải lên: 21/02/2014, 20:20
Báo cáo khoa học: Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization pptx
... ubiquitin-like proteins. They are responsible for the disassembly of ubiquitin chains, and for the cleavage of mono- and oligomers of this mole- cule, either in precursor form or attached to small Keywords biochemical ... the inhibitor of jB kinase, a regulatory role can be pre- sumed for USP7 phorsphorylation. The identification of K869 as the ubiquitination site of USP7 rep...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... order of phos- phate processing and the characteristics of protein–protein interactions turn out to be of overriding importance for both sensitivity and speed of response. Random phosphate processing ... order of phosphate processing. The transition time s is plotted as a function of K T ⁄ P T for different values of N in a sequential mechanism (A) and in a random mech...
Ngày tải lên: 07/03/2014, 10:20