Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors potx
Báo cáo khoa học: Ligand-specific dose–response of heterologously expressed olfactory receptors potx
... based on the median is traced. Ó FEBS 2003 Ligand-specific dose–response of olfactory receptors (Eur. J. Biochem. 270) 2909 Discussion Expression of olfactory receptors in surrogate cells is necessary ... response of receptors to odorants. Two mammalian olfactory receptors were used to initiate the study, the rat I7 olfactory receptor and the human OR17-40 olfactory...
Ngày tải lên: 08/03/2014, 02:21
Tài liệu Báo cáo khoa học: Specific membrane binding of the carboxypeptidase Y inhibitor IC, a phosphatidylethanolamine-binding protein family member doc
... phospholipid and membrane binding of the other members of the PEBP family. Consequently, the binding characteristics of PEBP proteins, including those of the binding of I C to phospholipid membranes, are ... cytoplasmic inhibitor of vacuolar CPY in the yeast Saccharomyces cerevisiae [1–3]. Recent biochemical and mutational studies of I C [4–8] and the crystal structure of the...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khóa học: The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer ppt
... the native form of Hfq has an apparent molecular mass of 50 ± 10 kDa, while the unfolded state of Hfq has an average apparent molecular mass of 12 ± 5 kDa. This indicates that the unfolded state of Hfq ... binding of the polyadenylated rpsO RNA. We have shown that the presence of the remainder of the acidic tail results in the thermodynamic stabilization of Hfq by 1.8 kcalÆm...
Ngày tải lên: 19/02/2014, 12:20
Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... various domains, is capable of controlling its enzymatic activity in all regions of the cell that it encounters. This mode of self-control is unique among members of all proteinases families. Abbreviations AMC, ... constitutive secretory pathway when overexpressed in GH4 or CHO cells [16]. This result was obtained after analysis of the enhanced conversion of human prorenin into ma...
Ngày tải lên: 30/03/2014, 08:20
Báo cáo khoa học: The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene pot
... mechanism of action of sumoylation of ERM is unknown and could potentially involve the regulation of interactions with cofactors. We have identified an interaction between CHD3 and the CIDD region of ... development of AD because of its role in cleavage of the amyloid pre- cursor protein (APP) and the production of Ab pep- tide, which is central to the pathogenesis of AD [9...
Ngày tải lên: 30/03/2014, 09:20
Báo cáo khoa học: Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA ppt
... are a class of disease-causing and immunostimulatory p roteins o f b acterial or viral o rigin t hat activate a large number of T-cells through interaction with the Vb domain of T-cell receptors ... and because of the potential use of the toxins as biological weapons. Alteration of their MHC and TCR binding capacity by site directed mutagenesis could be useful in the development...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: "Automatic Detection and Correction of Errors in Dependency Treebanks" potx
... found. The overall number of errors thus seems to be over 1% of the total size of a corpus, which is expected to be of a very high quality. A fact that one has to be aware of when working with ... we were not able to find a lot of work on the topic of error detection in treebanks. Some organisers of shared tasks usually try to guarantee a certain quality of the used da...
Ngày tải lên: 07/03/2014, 22:20
Báo cáo khoa học: Understanding the complex mechanisms of b2-microglobulin amyloid assembly potx
... milli- seconds of the population of I 1 and displays native-like secondary structure and ordered packing of side chains within the hydrophobic core. Further folding of I 2 occurs on a timescale of seconds ... the folding and unfolding kinetics of b 2 m under an array of conditions, including analysis of the folding mechanism of the variant P32G. Using global analysis of th...
Ngày tải lên: 28/03/2014, 22:20
Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway pdf
... formation of chan- nels for release of cytochrome c [61]. Thus, morphine seems to promote the proapoptotic effect of Bax by both enhancement of Bim expression and downregula- tion of Bcl-2 expression, ... via enhancement of the expression of the proapoptotic protein Bim and reduction of the expression of the antiapoptotic protein Bcl-2. ROS signaling exerts posi- tive feedba...
Ngày tải lên: 16/03/2014, 01:20
Tài liệu Báo cáo khoa học: Seed-based systematic discovery of specific transcription factor target genes pptx
... Number of genes Number of genes Number of genes Number of genes Fig. 5. Left column: cross-validation of the seed distribution method for six different transcription factors. By means of a jack- knife ... the case of c-Myc, the broad-spectrum ontologies [34]. The results of this jack-knife procedure also provide an estimate of how many of the true positives will lie in...
Ngày tải lên: 18/02/2014, 18:20