Báo cáo khoa học: Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters ppt

... that the drinking of green tea will have a prophylactic effect on cartilage Fig. 4. Inhibition of rhADAMTS-1, -4 and -5 by catechins and gallates. rhADAMTS-1 (A), -4 (B), and -5 (C) were assayed ... activity of ADAMTS-1, -4 and -5. The catechin gallate esters EGCG and ECG potently inhibited ADAMTS-1, -4 and - 5 in a dose-dependent man...

Ngày tải lên: 08/03/2014, 02:20

... differentiation, and so on. Isoforms of numerous proteins have been studied and compared in this man- ner, including alternative isoforms of members of the p53 ⁄ p63 ⁄ p73 [23] and the Bcl2 families ... versions of these two isoforms, as well as of the Mxi1-WR isoform that lacks the SID, and shown to give rise to proteins of the expected size expressed at similar levels (F...

Ngày tải lên: 18/02/2014, 16:20

... as expected. Analysis by ELISA of the interactions of EDIAs and Herceptin with soluble ErbB2-ECD ELISA sandwich assays were performed to determine the ability of Erbicin and EDIAs to recognize ... competition in the case of ERB-hcAb. Effects of soluble ErbB2-ECD on the cytotoxicity of ERB-hcAb and Herceptin On the basis of the results discussed above, the antitumour effe...

Ngày tải lên: 23/03/2014, 06:20

... precepting. However, neatly all of them are like obsorvem of the recent space shuttle: They can understand liftoff, landing and some of the discus=dons of the heat of re(retry, but the critical ... threat of an evaluation, and they are like the threat of a military inspection. All of the valuable effects are complete before the ins~oection takes piece. Of course, in...

Ngày tải lên: 08/03/2014, 18:20

... Tang, College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Shandong Normal ... DBZTC 2-chloro-1-formyl-3-hydroxymethylenecyclohexene [21] A solution of 40.0 mL of dimethylformamide in 40.0 mL of methylene chloride was chilled in an ice bath. A solution of...

Ngày tải lên: 16/03/2014, 11:20

... cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 270 , 21158–21166. Interaction of protein C with EPCR and phospholipids ... C through the selective inactivation of activated Factor V. Biochim Biophys Acta 571, 333–342. 10 Kalafatis M, Rand MD & Mann KG (1994) The mechanism of inactivation...

Ngày tải lên: 16/03/2014, 18:20

... the inhibition of Ras processing caused by HR12 was reversible, and relief of this inhibition correlated with the return of pRb phosphorylation. HR12 leads to an increase in p27 Kip1 levels and ... examined, Fig. 1. Inhibition of anchorage independent and dependent growth of Rat1/ras cells by HR12. (A) Rat1/ras cells were grown in a layer of 0.3% soft agar in a 96-...

Ngày tải lên: 31/03/2014, 01:20

... activity 100 200 300 pIFN-β(-125)-Luc 3-4A 3-4A Myc-Cardif NS (Strain) A (1B-1) (O) 3-4A S1165A 3-4A W1528A B Myc-Cardif dimer monomer Anti- EGFP (Strain) NS 3-4A 3-4A (1B-1) (O) 3-4A S1165A 3-4A W1528A IRF-3 C Myc-Cardif C508A (1B-1) 3-4A S1165A 3-4A W1528A 3-4A Myc-Cardif NS3 b -actin 75 k D a 50 37 100 (Strain) NS 3-4A 3-4A 3-4A 3-4A (1B-1) (O) Myc-Cardif (1B-1) (O) Fig. ... phosphorylatio...

Ngày tải lên: 18/02/2014, 16:20

... activity and mitochondrial CYP2E1 exhibits high NDMA-d activity. The activities of both micro- somal and mitochondrial enzymes were dependent on addition of NADPH and inhibited by SKF-525. In ... NADPH, and 4 mm NDMA in a 1.0 mL final volume. The reaction mixture was incubated at 37 °C for 30 min, and the reaction was stopped by the addition of 0.1 mL of 25% zinc sulfate...

Ngày tải lên: 18/02/2014, 16:20

... collected and suspen- ded in 25 mL of 40% potassium hydroxide and 25 mL of methanol and refluxed for 2 h. Products were extracted with 50 mL of hexane. The hexane layer was washed with 25 mL of saturated ... December 2005) doi:10.1111/j.174 2-46 58.2006.05120.x Triterpenes exhibit a wide range of structural diversity produced by a sequence of biosynthetic reactions. Cycli...

Ngày tải lên: 19/02/2014, 07:20