Báo cáo khoa học: Tumor necrosis factor-a converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation pptx

... resistance of the DNA ⁄ histone contacts, a mechanical unwrapping of DNA from the histone oct- amer will occur. If this release is discontinuous (i.e. a certain characteristic length of DNA is ... appeared not to be straightforward. Upon eviction of the histone octamer and histone H1 (i.e. the disruption of the chromatosome) 166 bp of DNA is expected to be released, i.e. 56.4 nm a...

Ngày tải lên: 14/02/2014, 18:20

... et al. (2001) The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276, 41245–41254. 38 ... investigations that include analysis of pancreatic islet cells. The H-PGDS TG mouse is a novel obesity model with which to investigate the mechanism of adipogene- sis. As...

Ngày tải lên: 16/02/2014, 09:20

... transcripts is regulated by a pathway independent of these two MAP kinases. It is possible that the modulation is due to the activation of JNK. Other MAP kinase inhibitors as well as G-protein inhibitors ... Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740–745. 7 Latz E, Verma...

Ngày tải lên: 18/02/2014, 13:20

... Sciences, Japan Persistent infection by hepatitis C virus (HCV) fre- quently causes chronic hepatitis [1,2], which progresses to liver cirrhosis and hepatocellular carcinoma [3,4]. This is a serious ... NF-kappaB by Toll-like receptor 3. Nature 413, 732–738. 14 Honda K & Taniguchi T (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pat- tern-rec...

Ngày tải lên: 18/02/2014, 16:20

... similar from a regulatory point of view. dCMP deaminase is activa- ted by dCTP and inhibited by dTTP and both nucleo- tides act on the enzyme by binding to an allosteric site to alter the cooperativity ... dCTP and is inhibited by dTTP. Our results suggest that regulation of dCTP deaminase is not by a conventional allosteric mechanism, but appar- ently utilizes the prope...

Ngày tải lên: 18/02/2014, 16:20

... Eukary- otic topoisomerase II is another target of protein kinase CK2 which is essential for viability. However, the importance of CK2 phosporylation of topoisomer- ase II is not well understood, because ... of processes, although within narrow limits, is likely to be detrimental to cell life. Thus, moderate activation of the Rio1p kinase upon phosphorylation by CK2 is in...

Ngày tải lên: 18/02/2014, 16:20

... common form of TTr; 13881, the common form of TTr disulfide-linked to cysteine; 13792, a variant form of TTr that may consist of G6S change; 13911, the variant protein that is disulfide- linked to ... of b-VLDL to low-density lipoprotein receptor-related protein [1,2]. It is implicated in regulation of several lipase enzymes [3–5]. An N-terminal 38-residue form of ApoC1 is a...

Ngày tải lên: 19/02/2014, 05:20

... the observed Zn 2+ inhibition [15]. T his enzyme is a homo- dimeric molecule which contains FAD and belongs to the NAD-disulphide oxidoreductases class I group, which is led by the glutathione reductase ... obtained by expression in E. coli. B riefly, a pET28-Fd expression vector was con- structed by inserting the cDNA corresponding to the mature pea Fd i nto the pET28a v...

Ngày tải lên: 19/02/2014, 16:20

... domain in its isolated form and in complex with RNAs and ⁄ or proteins. This review shows how such a simple domain can modulate its fold to recognize many RNAs and proteins in order to achieve ... RNA-binding platform to regulate post-transcriptional gene expression Christophe Maris*, Cyril Dominguez* and Fre ´ de ´ ric H T. Allain Institute for Molecular Biology and Biophysics, S...

Ngày tải lên: 19/02/2014, 17:20

... cytoplasm and then translocated into the central vacuole, by mechanisms yet to be fully characterized. The aim of this work was to determine whether a homologue of rat liver bilitranslocase is ... on their protonation [15]. The third model is an ATP-energised mechanism catalysed by ATP-binding cassette transporters. They are insensitive to protonophores, strongly inhibited by...

Ngày tải lên: 20/02/2014, 01:20