Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx

... results in >95% pure protein (Fig. 1). Antibodies raised against the hemocyanin fraction show staining of the two 75 kDa bands in Western blot, but do not recognize any other proteins of the hemolymph. Although ... lost during the evolution of the Spirostreptidae (Fig. 5). The reason for different hemo- cyanin function and thus structure of Scutigera and Spiro...

Ngày tải lên: 20/02/2014, 11:20

... it is of interest to understand the mode of action of these proteins in M. tuberculosis. In this study, we functionally characterized the ClpC1 protein of M. tuberculosis, and investigated the role ... [3]. Increased expression of heat shock proteins is triggered by a range of stress conditions, and is also induced in both the host and pathogen during the...

Ngày tải lên: 23/03/2014, 06:20

... describes the relation of the total leaf area of a plant (one side) to the covered ground area. This can range from 4 to 16 for different types of forests, and leaf area index values of 1–5 can be found ... downstream of primary photosynthesis, leading to a re-orientation in the metabolic network of plants by affecting, for example, carbohydate metabo- lism and th...

Ngày tải lên: 16/03/2014, 06:20

... is, Ω(y) is the set of parses of a string y and F( y) is the set of features appearing in the parses of y. In the gram- mars of interest here Ω(y) and hence also F( y) are finite. Maxwell and Kaplan’s ... as the value that maximises a product of functions or else as the sum of a product of functions, each of which depends on a small subset of the v...

Ngày tải lên: 31/03/2014, 06:20

... initially identified as an Abl SH3 domain-binding protein of unknown func- tion [25]. Recently, 3BP2 has been shown to interact with the Syk and ZAP70 proteins of the Syk family of tyrosine kinases. ... activation [35]. In RBL- 2H3 mast cells, phosphorylation of Tyr448 of 3BP2 creates a binding site for the SH2 domain of Lyn, a Src family protein tyrosine kinas...

Ngày tải lên: 07/03/2014, 12:20

... Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck Hazel R. Housden 1 , Paul J. S. Skipp 1 , Matthew P. ... restriction to Lck accessing certain tyrosine residues of the protein chain. Our studies have determined the efficiency of phosphory- lation of e...

Ngày tải lên: 08/03/2014, 02:20

... This is indicated by the average activity of mutants in the central domain of 26% for WAF1 and 34% for MDM2, 71% for NOXA and 61% for p53R2, and around 45% for the other four promot- ers. For some ... additional binding site needed for the WAF1 promoter. Prediction of the severity of mutants in other proteins All parameters used for the predictions of p53 cou...

Ngày tải lên: 18/02/2014, 11:20

... to introduce the mutations of His fi Leu for the three histidine residues of interest within the third transmembrane domain of Nox2. Each of the three possible combinations of pairs of histidine ... particle and release of its genome into the cell [18,23]. Therefore, the in ux of protons through the M2 protein is important in the life cycle of the vir...

Ngày tải lên: 07/03/2014, 16:20

... exclusively from the l ength increase of these interactions. This also indicates that the length decrease of the residue 39 side -chain affects /4e and /4a interactions equally. Replacement of Q39 with ... ratio, the mutation series E fi D fi S may be useful in changing the preference for glucosides and galactosides of other family 1 b-glycosidases. The preference for...

Ngày tải lên: 16/03/2014, 18:20

... surface of the bind- ing site, and this polarization effect can be obtained by using the QM description of the ligand. Looking at the electronic structure of the ligands in their bounded conformations, ... site, by using the so-called ‘blind docking’ approach, a technique introduced for the detection of possible binding sites and modes of binding of peptide...

Ngày tải lên: 23/03/2014, 07:20