Báo cáo khoa học: Utilizing logical relationships in genomic data to decipher cellular processes pptx

... MINIREVIEW Utilizing logical relationships in genomic data to decipher cellular processes Peter M. Bowers 1,2, *, Brian D. O’Connor 3, *, Shawn J. Cokus 4 , Einat Sprinzak 2 , Todd O. ... suc- cessfully to other types of genomic data? We analyzed logical relationships within microarray expression data, with attention to identifying logical combinations of pr...

Ngày tải lên: 07/03/2014, 21:20

... dimeric form in which the chains swap their N-termini, and an unswapped dimer. In the cytosolic reducing environment, the dimeric form in which the chains swap their N-termini is converted into a noncovalent dimer ... NCD), in which the monomers remain intertwined through their N-terminal ends. The quaternary structure renders the reduced pro- tein resistant to the ribonuclease inhi...

Ngày tải lên: 22/03/2014, 17:20

... family, binding to and inhibit- ing these signaling molecules from binding to their receptors in the extracellular space, thus inhibiting ven- tralizing activities. Of these proteins, Chordin has ... and bind to the type I and type II receptors on the cell surface. These receptors are serine ⁄ threonine kinase receptors with a single transmembrane domain. Bind- ing of the ligand to...

Ngày tải lên: 19/02/2014, 00:20

... culture of infected hepatocytes. To succeed in obtaining HCV infection in primary human hepatocytes, an existing model of hep- atitis B virus infection was used to determine optimal infection ... by the poor binding inhibition achieved in the presence of mAbs directed against CD81. In contrast, heparin sul- fate seemed to mediate this interaction [53]. Taking advantage of this b...

Ngày tải lên: 16/03/2014, 05:20

... represented as a set of factors. The model scores each factor using a weight vector w that con- tains the weights for the features to be learned dur- ing training using the Margin Infused Relaxed Algo- rithm ... templates in which we add the DLM-based features in the de- coding algorithm directly. 4.1 Rescoring We add the DLM-based features into the decoding procedure by using the resco...

Ngày tải lên: 23/03/2014, 14:20

... learn- ing binary classifiers. High-quality sense- annotated data, however, are hard to be ob- tained in streaming environments, since the training corpus would have to be constantly updated in order ... evolving databases. In Proceedings of the Second SIAM International Conference on Data Mining, Arlington, USA. A. Veloso, W. Meira Jr., and M. J. Zaki. 2006. Lazy associative clas...

Ngày tải lên: 30/03/2014, 17:20

... first milestones in Intelligent Tutoring Systems (ITS) was Carbonell's system (1970) that used a knowledge-base to check the student's answers and to allow him/her to interact in "natural ... double generating examples in standard French and in the local dialect using linguistic resources usually used in machine translation. Introduction The project that...

Ngày tải lên: 31/03/2014, 04:20

... Ras protein as a new tool, paving the way to revealing the dynamic interactions of mem- brane-bound N-Ras protein with its effectors and regu- lators (i.e. Ras binding domain of Raf, guanine nucleotide ... protein incor- poration was initiated by mixing the protein into the sample solution on the surface. The starting bulk concen- tration of the protein was approximately 2.0 lm in a buffe...

Ngày tải lên: 07/03/2014, 04:20

... Planner: Processing INIT Planner: Processing DELIBERATE Warning Repairing Planner: Processing REJECT Trying to find a dialogue act to bridge DELIBERATE and REJECT Possible insertions and ... currently integrate the speaker direction into the prediction process which results in a gain of up to 5 % in the prediction hit rate. Additionally, we in- vestigate methods to...

Ngày tải lên: 08/03/2014, 07:20

... prerequisite for cytotoxicity. In fact, the hemolytic domain of SMAP-29 was also shown to overlap with an LPS- binding site at the C-terminal end [25]. To determine whether the two LPS-binding sites act in a ... conformation with a slight kink induced by gly- cine close to the center, in addition to a short flexible unstructured region near the N terminus. To gain further insig...

Ngày tải lên: 30/03/2014, 11:20