... recognition in the normal splicing process [55]. First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of ... 855 MINIREVIEW Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies Ashish Dhir and Emanuele Buratti International Centre for Genetic Engineering...
Ngày tải lên: 06/03/2014, 09:22
... performed with a standard protocol using the biotin–avidin-based Vectastain Elite kit (Vector Laboratories) and diamino- benzadine (DAB) for detection of the secondary anti- body, according to the protocol ... of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunol- ogy 105, 375–390. 5 Caughey G (2001) New developments in the genetics an...
Ngày tải lên: 07/03/2014, 11:20
Báo cáo khoa học: "Intensional Summaries as Cooperative Responses in Dialogue: Automation and Evaluation" ppt
... the attribute cuisine in a restaurant domain has val- ues such as “French” or “Italian”. A user utter- ance instantiating a constraint on cuisine, e.g., “I’m interested in Chinese food”, results in a set of ... restaurants in London. SI1: What kind of cuisine are you interested in? C1: I know of 596 restaurants in London. I know of 3 inexpensive vegetarian restaurants and 14 ine...
Ngày tải lên: 08/03/2014, 01:20
Tài liệu Báo cáo khoa học: "Automatic Detection of Nonreferential It in Spoken Multi-Party Dialog" doc
... something. The task of the system described in the follow- ing is to identify and filter out nonreferential in- stances of it, like the first and second one in the example. By preventing these instances ... a single speaker and contains start and end time information. The transcription con- tains manually added punctuation, and it also ex- plicitly records disfluencies and spee...
Ngày tải lên: 22/02/2014, 02:20
Báo cáo khoa học: "Methods for Using Textual Entailment in Open-Domain Question Answering" doc
... were clustered using complete-link cluster- ing using a technique proposed in (Barzilay and Lee, 2003). 3.3 Creating New Sources of Training Data In order to obtain more training data for our ... phenomena that are in- volved in determining answerhood. Our work suggests that considerable gains in performance can be obtained by incorporating TE during both answer processing and p...
Ngày tải lên: 08/03/2014, 02:21
Báo cáo khoa học: "Automatically Assessing the Post Quality in Online Discussions on Software" docx
... stud- ied in the area of automatic essay scoring (Valenti et al., 2003; Chodorow and Burstein, 2004; Attali and Burstein, 2006). While there exist guidelines for writing and assessing essays, ... repositories of information and find information of high qual- ity quickly. In order to address this problem, many forum hosting companies like Google Groups 1 and Nabble 2 introduce rat...
Ngày tải lên: 08/03/2014, 03:20
Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
... amino acid in the cata- lytic centre. This latter singular class of proteins, called chitinase-like proteins (CLPs), has been identified only recently in plants [2], mammals [3], insects [4] and ... by incubating sections in 0.3% hydrogen peroxide in methanol for 30 min at room temperature. Slides were then washed and incubated in a blocking solution accord- ing to the manufac...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... crystallins, their interactions with one another, with membranes [13,29], and with cell components such as actin [30] and the intermediate filament proteins CP49 and filensin [31]. a-crystallins maintain ... aA- crystallin requires this domain [66]. Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and...
Ngày tải lên: 19/02/2014, 18:20
Báo cáo khoa học: Computer-assisted mass spectrometric analysis of naturally occurring and artificially introduced cross-links in proteins and protein complexes potx
... structures, chemical modifications and cross-linking in protein mixtures, complexes, and assemblies. Proteins A single protein, a list of proteins from a mixture or from a protein complex or a complete ... analysis of naturally occur- ring cross-links, e.g. disulfide bonds, and artificially introduced cross-links in proteins. Cross-links impose distance constraints on amino acid r...
Ngày tải lên: 07/03/2014, 12:20
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... with GST-CD2 (MAP2 v-KIND binding core). Input (cerebellum) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND Input (MAP2) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND PD from cerebellar ... stain) EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 KIND2-1 487 KIND2-2 521 KIND2-3 555 KIND2-5 589 KIND2-4 488 456 620 KIND2 v-KIND + + + – – I...
Ngày tải lên: 14/02/2014, 19:20