Báo cáo khoa học: Reactions of gold(III) complexes with serum albumin docx

... hydrophobic molecules; more- over albumins bind various metal ions [8]. The reactions of gold(III) complexes with serum albumin were investigated primarily through the analysis of the Correspondence to ... the subject of further biochemical and pharmacological inves- tigations [1]. Studies of the interactions of these gold(III) complexes with DNA, the classical tar...

Ngày tải lên: 07/03/2014, 21:20

... and temporal expression of specific subsets of genes. The sequential silencing of genes involved in maintenance of pluripotent and multipotent states and the activa- tion of those involved in differentiation ... transcription complexes, often referred to as transcription factories [30]. It is possible that one of the early events in globin locus activation involves the associatio...

Ngày tải lên: 07/03/2014, 12:20

... a large amount of enzyme–substrate complex compared with the total concentration of the interconvertible enzyme may reduce the sensitivity of the cycle. They did not analyse any of the general ... transduction cascades often exhibit comparable amounts of protein substrates and enzymes [16]. For example, the individual concentrations of Table 1. Concentrations of members of t...

Ngày tải lên: 19/02/2014, 07:20

... points, independent of concentration of a-MSH, as compared with the non- transfected cells. The cells transfected with hMC4-E100K, in contrast with the chicken receptors with Lys in position 92, ... concentrations of a-MSH, the cAMP levels were lower than that observed for the cells transfected with e b ,Eand E R . All experiments were performed with a similar number of ce...

Ngày tải lên: 21/02/2014, 00:20

... within 3 A ˚ of N5 of the isoalloxazine ring of the flavin. Agmatine, however, binds poorly to MAO-A, giving only 50% inhibition of the oxidation of 0.3 mm kynuramine at 1 mm. Docking of imidazolines ... inhibition of MAO with a mechanism- based irreversible inhibitor did not prevent binding of the I 2 ligand 2-(2-benzofuranyl)-2-imidazoline (2-BFI), suggesting that the I 2 B...

Ngày tải lên: 07/03/2014, 10:20

... First, the algorithm starts with a set of trees consisting of single nodes, and then expands a given tree of size (n−1) by attaching a new node to it to obtain trees of size n. However, it would ... highly correlated with each other. Even when we exploit all subtrees, most of them are extremely redundant. The motivation of this paper is based on the above observation. We think...

Ngày tải lên: 08/03/2014, 04:22

... [33], with yields of 10–50 mg from 1 L of cul- ture medium. The crystallization of RNase Sa2 with a free active site was performed as described previously [32]. Complexes of RNase Sa2 with 2¢-GMP ... command of glide. Interactions of probe atoms with proteins were calculated with the Receptor Grid Generation command of V. Bauerova ´ -Hlinkova ´ et al. Structures of...

Ngày tải lên: 18/02/2014, 11:20

... (2005) Conversion of human alpha-lactalbumin to an apo-like state in the complexes with basic poly- amino acids: toward understanding of the molecular mechanism of antitumor action of HAMLET. J Prote- ome ... acid complexes of a-lactalbumin fragments FEBS Journal 277 (2010) 163–173 ª 2009 The Authors Journal compilation ª 2009 FEBS 173 The oleic acid complexes of proteolyt...

Ngày tải lên: 06/03/2014, 09:22

... at 4 °C with 250 lL of phenol ⁄ chloroform (5 : 1, pH 4.7) and 100 lL of Zirconia beads (Ambion, Applied Biosystems, Warrington, UK). The aqueous phase was mixed with an equal volume of 2 · RNA ... Lsm8p N-termini prevent aggregation of the Lsm complexes, potentially by interacting with the prion- like C-terminal domain of Lsm4p. This asparagine-rich region of Lsm4p plays a...

Ngày tải lên: 07/03/2014, 02:20

... one unit of our ICU, we implemented an ICIS with incorpo- rated CPOE and a moderate level of CDSS. The objective of this study was to evaluate and compare the incidence and severity of medication ... completely unaware of the ongoing study. As it was not possible to screen every patient on a daily basis because of lack of time, patients were picked with a minimal pause of...

Ngày tải lên: 25/10/2012, 10:39