Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot

... The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure Michiko Kato 1 , Yasuhiro ... vitro,aswellasfor maintaining CPY in an inactive form [4–6]. The mature and precursor forms are glycoproteins [7], which contain % 16% ca...

Ngày tải lên: 07/03/2014, 21:20

... proteins Targeting signals Analysis of dual targeting signals indicates that they are rather similar to plastidic and mitochondrial tar- geting signals, in that they are enriched in positively charged ... processing site have a greater inhibitory affect of MPP compared to SPP. In the case of aminoacyl tRNA synthetases, Glu aminoacyl-tRNA synthetase was processed at the sam...

Ngày tải lên: 07/03/2014, 03:20

... centrality instead of degree centrality. IC: same as DC except for using information cen- trality instead of degree centrality. FQ: including Frequency and all other non- centrality features. The ... actors. A social network is composed of a set of actors and the rela- tion or relations defined on them (Wasserman and Faust, 1994). Graph theory has been used in soc...

Ngày tải lên: 23/03/2014, 19:20

... enzymes through the use of ThDP analogues. Many such analogues have been syn- thesized and have provided information on the functional groups necessary for the binding and catalytic activity of the cofactor. ... and the ordering of the C-terminus of the protein to form a lid over the CoA chain (PDB entry 2JI6) [34]. In the case of phenylpyru- vate decar...

Ngày tải lên: 29/03/2014, 23:20

... 95 °C at a heating rate of 0.5 °CÆmin )1 . The reversibility of the thermal transition was evaluated by several cycles of heating and cooling. The standard micro- cal origin software was used ... cycle of heating and cooling, there was a distortion with the appear- ance of a low-temperature endotherm (Fig. 8A, scan 2). The heat capacity curves for the second...

Ngày tải lên: 07/03/2014, 05:20

... in ammatory responses [85]. In addition, the slight edema of astro- cytes helps maintain the water balance in the brain, but pathologic cytotoxic edema is a main cause of increased intracranial pressure ... that astrocytes play active roles in various brain functions. In particular, astrocytes function as adult neural stem cells, participate in the formation and m...

Ngày tải lên: 18/02/2014, 11:20

... fat bodies were collected and RNA lev- els were analyzed using qPCR. Transcript abundance values for AaEcRA, AaEcRB, AaUSP -A, AaUSP-B, AaE7 5A (A) , AaHR3, AaHR4, AaE78, AaHR39, AaHR78 (B) and AabFTZ-F 1A, ... biological repli- cates were analyzed, and Fig. 2 depicts the profile matching both replicates. An increase in transcript abundance for AaEcRA, AaEcRB, AaE7 5A, AaE75B, AaE75...

Ngày tải lên: 18/02/2014, 13:20

... kcalÆmol )1 of increased stability). This was evident in the folding pathway for the Arg-Glu mutant via both a slightly faster folding rate and a vastly decelerated overall unfolding rate, relative to the ... dissociation is fun- damental in lead design and synthesis of peptide-based antagonists that aim to bind and sequester proteins that are behaving abnormally. Of...

Ngày tải lên: 18/02/2014, 13:20

... WASP)-binding domain and a novel C-terminal actin-binding domain Thirumaran Thanabalu 1,2 , Rajamuthiah Rajmohan 2 , Lei Meng 2 , Gang Ren 4,5 , Parimala R. Vajjhala 4 and Alan L. Munn 1,3,4,6 * 1 Institute ... filament assembly machinery or whether it has a more general role in stabilizing or altering protein conformation and that regulation of the actin-filament assembly machi...

Ngày tải lên: 18/02/2014, 16:20

... due to amino acid biosynthesis. Much of the generation of NADH during amino acid biosyn- thesis takes place in the mitochondria. Because of the block in the respiratory chain caused by the addition of ... subdivided into pre- and post-genome duplication lineages. Appar- ently, the duplication took place after the separation of Saccharomyces, Kazachstania, Naumovi...

Ngày tải lên: 19/02/2014, 02:20