Báo cáo khoa học: The binding of IMP to Ribonuclease A pptx

... inhibitors. Thus, although the Table 4. Van der Waals interactions of IMP and AMP in the active site of RNase A. IMP ⁄ AMP atom RNase A IMP RNase A AMP IMP Mol I IMP Mol II IMP Mol III RNase A Mol ... respectively. The shape correlation statistic Sc [33] is 0.77 for the association of AMP to the active site of RNase A. Comparative structural analysis Alth...

Ngày tải lên: 07/03/2014, 21:20

... subset of information that is needed to determine the meanings of the sentences actually presented to the system. Dynamic model-theoretic semantics allows the evaluation of a formula to cause the ... ABSTRACT Model-theoretic semantics provides a computationally attractive means of representing the semantics of natural language. However, the models use...

Ngày tải lên: 21/02/2014, 20:20

... was similarly amplified with primers H10VLframe2 (5¢-GGCAACAACCTACACTGGTATCA ACAAAAAYMGSRCRAATCTCCTCRGCTCCTGRTCW AKTATGCTTCCCAGTCCATCTCT-3¢) and g7EcoFor (5¢-AGTGAATTCTCATCTTTGACCCCCAGCGATTAT ACCAA-3¢). ... (5¢-GTCCTCGCAACTGCGGCCC AGCCGGCCATGGCCSARGTNMAGCTGSAGSAGTC WGG-3¢) and H10VHframe2 (5¢-ACCACTGTAGCTT ACGTACCCCAWSYACTCCAGACSKTTACCTGGARR TTKACGAAYCCAGCTCCAATAATCACTGGT-3¢) with pKST2(HyHEL-...

Ngày tải lên: 07/03/2014, 12:20

... Plecoptera, Dermaptera, Orthop- tera, Phasmatodea, Mantodea, Isoptera and Blattaria, but not in Protura, Diplura, Ephemeroptera, Odonata and the Eumetabola (Holometabola + Hemiptera) (Fig. 3). In addition, ... Hexapoda and provides strong evidence for the monophyly of the Polyneoptera (Plecoptera, Dermaptera, Orthop- tera, Phasmatodea, Mantodea, Isoptera, Blattaria) and the Dictyopt...

Ngày tải lên: 18/02/2014, 08:20

... were calculated from the standard errors associated with the means of the measured values (i.e. by calculating the square root of the sum of the associated individual errors squared). The maximum ... ⁄ w ratio of a- lactalbumin : aB-crystallin decreased the precipi- tation of a- lactalbumin by 81 ± 8%. The ability of A C B Fig. 1. The effect of additives...

Ngày tải lên: 18/02/2014, 16:20

... con- sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes (6- to 10-mer sample). (A) (a) Nonamer of a sequential single helix. (b, c) Sedimentation ... mononucleosomes and the band S. DNA gel electrophoresis of the fractions from Fig. 3D,E showed that approximately 90% of the DNA in the main peak as well as th...

Ngày tải lên: 18/02/2014, 18:20

... also affect the function of human topoisomerase I by alteration of DNA cleavage patterns [20]. The greatest disturbance of DNA cleavage is caused by the (+)-trans-B [a] P-N 2 -dG and (+)-cis- B [a] P-N 2 -dG ... within the catalytic domain of the M.HhaI with the DNA minor groove play an important role in the methylation reaction. The contacts of the M.HhaI small do...

Ngày tải lên: 19/02/2014, 00:20

... skeletal dysplasias of variable severity including the lethal neonatal thanatophoric dysplasia types I (TDI) and II (TDII). To elucidate the role of activating mutations causing TDI on receptor traffick- ing ... S & Stewart AK (2004) Preclinical stu- dies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br J Haematol 124, 595–603. 38 Maeda T,...

Ngày tải lên: 19/02/2014, 00:20

... sur- face’ is more similar to that of BS-RNase because of the removal of the four carboxylates. The ‘basic sur- face’ of the mutant HHP-RNase is very similar to that of RNase-AA-GG as the presence ... destabilize and permeate a membrane, which in turn appears to be linked to the attraction of the RNase to a membrane, as evidenced by the RNase negative...

Ngày tải lên: 19/02/2014, 06:20

... proliferator-activated receptor (PPAR) alpha are members of the nuclear receptor superfamily. Whereas PPARalpha is activated by fatty acids, FXR has recently been identified as a bile acid-activated ... syndrome and adipocytokines Y. Matzuzawa Department of Internal Medicine and Molecular Science, Graduate School of Medicine Osaka University, Osaka, Japan Visceral fat accumulation pl...

Ngày tải lên: 19/02/2014, 07:20