Báo cáo khoa học: Allosteric functioning of dimeric class C G-protein-coupled receptors doc

... and allosteric modulation of FA1 are reduced. (b) Cooperation of accessory sites and FAx is almost unaffected. Finally, (c) the asymptotic absorbance of the Mn(III)heme–HSA complex (A 10 ) becomes ... analysis of the myristate-dependent conformational changes of the N and B states of Mn(III)heme–HSA, by optical absorb- ance spectroscopy and NMR spectroscopy, that show allosteri...

Ngày tải lên: 20/02/2014, 02:22

... meth- odological approaches and physiological relevance. Curr Med Chem, 9, 1463–1481. 5 Kragh-Hansen U, Chuang VT & Otagiri M (2002) Practical aspects of the ligand-binding and enzymatic properties of ... Ascenzi P & Smulevich G (2008) Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation....

Ngày tải lên: 16/02/2014, 14:20

... The selected sequences and their accession codes are presented in Table 1. A multiple sequence alignment of the 79 selected sequences was constructed by a combination of T - COFFEE and CLUSTALX programs ... AF127082–3 Thermobifida fusca Bacteria ZP_00058751.1 Pyrococcus abyssi Archaea NP_126828.1 Pyrococcus furiosus Archaea NP_578544.1 Pyrococcus horikoshii Archaea NP_143154.1 Sulfolobus t...

Ngày tải lên: 19/02/2014, 13:20

... (1). The character type fea- ture CF (m i ) is a set of four binary flags to indi- cate that the surface string of m i contains a Chinese character, a hiragana character, a katakana charac- ter, ... to ex- tract NEs including unfamiliar words which do not occur or occur few times in a training corpus is nec- essary. This paper proposes a novel method of extract- ing NEs which contain unf...

Ngày tải lên: 20/02/2014, 09:20

... the sec- ond column represents the accuracy of the clas- sification in each data set. The third and fourth 457 Table 5: Classification result. Accuracy Positive Negative Precision Recall Precision ... this kind of sentences, we think discourse analysis is inevitable. 5.3 Application to opinion classification Next, we applied our corpus to opinion sentence classification. This is a task of c...

Ngày tải lên: 20/02/2014, 12:20

... density of observations in the corpus, shown in the first column of Table 3. The SF direct object direct object & clause direct object & infinitive clause infinitive occurrences ... simplicity, speed, and accuracy, over efficient use of the corpus. There are various ways in which the high-priority criteria can be traded off against efficiency. For example, consider...

Ngày tải lên: 20/02/2014, 21:20

... range of automatic metrics applied including inter alia ex- act match, string edit distance, NIST SSA, BLEU, NIST, ROUGE, generation string accuracy, gener- ation tree accuracy, word accuracy (Bangalore ... the sentences used, usually because of differences in punctuation. Hence this exact match upper bound. An upper bound in terms of BLEU score cannot be computed because BLEU score is...

Ngày tải lên: 22/02/2014, 02:20

... C- terminal domain of CA, comprising residues 146–231 of the intact protein; CACW40A, mutant of CAC with Ala instead of Trp at position 184 of CA; CSA, chemical shift anisotropy; Gag, the structural retroviral ... can be calcu- lated as a function of changes in polar and apolar surface areas of the binding interface, according to: DS sol = DC p ln(T ⁄ 385), where DC p is the he...

Ngày tải lên: 07/03/2014, 06:20

... Spalletti-Cernia D, Laccetti P, Cinatl J, Matousek J & D’Alessio G (1999) A dimeric mutant of human pancreatic ribonuclease with selective cytotoxi- city toward malignant cells. Proc Natl Acad Sci USA 96, ... Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carb...

Ngày tải lên: 19/02/2014, 06:20

... Open Access Available online http://ccforum.com/content/9/4/R303 R303 Vol 9 No 4 Research Circadian pattern of activation of the medical emergency team in a teaching hospital Daryl ... nursing and medical activities. Method We conducted a retrospective observational study of the time of activation for 2568 incidents of MET attendance. Each attendance was allocated to one of 48 ha...

Ngày tải lên: 25/10/2012, 10:45