... model of this molecule was generated bythe program corina (http://www.2.ccc.uni-erlangen.de ⁄ software ⁄ corina ⁄ free_struct.html) [60]. This 3D model wasfitted manually into the active site ... inhibitorconstants. Biochem J 55, 170–171.50 Leatherbarrow RJ (1992) Grafit, Version 3.0. Erithacus Software Ltd, Staines, UK.51 Otwinowski Z & Minor W (1997) Processing of X-raydiffraction ... Jiang JS, Kuszewski J,Nilges M, Pannu NS, et al. (1998) Crystallography &NMR system: a new software suite for macromolecularstructure determination. Acta Crystallogr D 54,905–921.62 Bru¨nger...