Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx

... by the observation that only a trace of the pro- tein was left in the unbound fraction. Pre-incubation of the recombinant protein with FP abolished most of this binding, suggesting that binding ... Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum Shin-ichiro Kawazu 1,2 , Nozomu Ikenoue 1 , Hitosh...

Ngày tải lên: 07/03/2014, 17:20

... helix–span–helix domain at the C-terminus shown in blue medi- ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical in all sequences in the align- ment; ... domain at their C-terminus, and a less conserved proline-rich and glutamine-rich transactiva- tion domain at their N-terminus [8–10]. Most isoforms also have a PY-motif (...

Ngày tải lên: 16/02/2014, 09:20

... and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 expression ... division, as a result of the defective migration of the spindle during cytoki- nesis. In this case, the depletion of Hsp90a in the absence of HSF1 affects...

Ngày tải lên: 18/02/2014, 04:20

... per monomer of poly(dT), showing that the changes were mainly due to the binding of the first DNA, while the binding of the second DNA had less in uence (Fig. 5A). To ensure that the estimation of the ... to examine whether these loops are actually involved in DNA binding. Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA-...

Ngày tải lên: 19/02/2014, 06:20

... of these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each ... the roles of the arginines in individual AAA+ modules were not elucidated. The role of the other conserved arginine (P2) in AAA-1 was also unclear. Here, w...

Ngày tải lên: 06/03/2014, 00:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For ... demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and ⁄ or bind...

Ngày tải lên: 06/03/2014, 01:20

... over- expressed in more than one-third of all solid tumors [20]. During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming ... mole- cules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11]. Roles of MMPs...

Ngày tải lên: 15/03/2014, 00:20

... an in vivo assay using a plasmid containing a single AP site in the stop codon of the gene encoding enhanced green fluorescent protein, > 80% of the repair accompanying the reversion of the ... the repair of other base lesions or the AP site also sugges- ted essential roles of Polb in the short-patch BER pathway [34–36]. Involvement of Polb in the sho...

Ngày tải lên: 16/03/2014, 13:20

... ade- ninylpentylcobalamin (AdePeCbl), an inactive coen- zyme analog, revealed the presence of the adenine- binding pocket in the active site of the enzyme [21] (Fig. 1A). The adenine ring of the ... 2008) doi:10.1111/j.1742-4658.2008.06745.x The X-ray structure of the diol dehydratase–adeninylpentylcobalamin com- plex revealed that the adenine moiety of adenosylc...

Ngày tải lên: 23/03/2014, 06:20

... be involved in the integration in the control of energy metabolism and stress responses, whereas the underlying detailed mechanisms need further investigation. RFRP The mammalian members of the ... neu- rons in the brainstem express estrogen receptors and that PrRP expression in the brainstem is higher in female than in male rats [24]. Thus, the function of P...

Ngày tải lên: 29/03/2014, 21:20