Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase pptx

... posi- tioned in the connecting loops. Approximately one- third of all mutations in the BTK gene are missense and some of these reduce the stability of the protein. This is exemplified by mutations in the ... identify individuals with mild disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome...

Ngày tải lên: 14/02/2014, 18:20

... significantly increases the cost of the purification, and the require- ment for HPLC increases the length and complexity of the purification procedure. Moreover, as with the studies by Lee et al. [21] and Subramanian ... Subramanian and Shree [42], there was no rigorous assessment of the purity of the product or the correctness of the sequence. In con- trast...

Ngày tải lên: 18/02/2014, 13:20

... comparison of rhodamine uptake, in the presence and the absence of uncouplers, allows the estimation of the effect of intracellular binding on the MDR phenomenon. The data detailed obtained in the present ... quenching of the dyes; and (c) it measures the total dye amount associated with the cells, including the dye adsorbed to the sur- face of the ce...

Ngày tải lên: 18/02/2014, 13:20

... [16,19,20,23]. The energy of folding these vari- ous forms and the energetic cost of converting one form to another is of fundamental importance for understanding telomere biology and the interactions of small ... fully understand such allosteric effects, the energetics of the underlying conformational transitions in quadruplex structures must be determined. The th...

Ngày tải lên: 06/03/2014, 09:22

... the effect of the length of these regions on the distribution. The intronic and intergenic regions were then classified on the basis of their lengths. Within each of the length groups, the numbers of ... there are also a large number of (CA) n and (GA) n repeats in the human genome, the frequency of their complementary repeats (TG) n and (CT) n is much low...

Ngày tải lên: 07/03/2014, 00:20

... animation; they are not alive in the sense the we enjoy life but neither are they able to die as long as nutrition, hydration, ventilation, and perfusion are assured. In many cases reanimation of such patients ... maintaining some of the vital functions of the body, but the same technology does not necessarily allow us to heal underlying disease processes [2]. An unintended...

Ngày tải lên: 25/10/2012, 10:45

... birds, mammals and corals is the dmrt gene family [5]. The prototype members of this group of factors are the Drosophila doublesex (dsx) and Caenor- habditis mab-3 genes. The Dmrt group of molecules ... gene is the product of a gene duplication of the autosomal dmrt1a gene and was designated dmrt1bY [8] or Dmy [9]. It was shown to be the only functional gene in...

Ngày tải lên: 14/02/2014, 19:20

... the condensation and fragmentation of their nuclei. The percentage of apoptotic cells was calculated as the number of apoptotic cells divided by the total number of cells counted. A minimum of ... lost. Taken together, our results demonstrate an impor- tant relationship among the regulation of nucleo- lin ⁄ C23, the activation of caspase-3 and the induction of...

Ngày tải lên: 16/02/2014, 09:20

... Institute and Hospital and the National Foundation of Cancer Research. All of the tumor types were confirmed by pathologic analysis. The experiments were undertaken with the understanding and written ... containing the mutations of the miR-23a binding site (Fig. 4A). It was shown that miR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP fluorescence i...

Ngày tải lên: 18/02/2014, 04:20

... erva- tamin-A, the P3 moiety of both the molecules of the asymmetric unit runs along the extended backbone of residues 65–64 and is partly exposed to the solvent (Fig. 2B). On the other hand, the P3 ... proton from the catalytic Cys pres- ent at the N-terminus of the helix to the His of the dyad [19,50,51]. The first stage of catalysis is mediated by th...

Ngày tải lên: 18/02/2014, 16:20