... picolinicacid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the final fate of the amino acid, i.e. transformation ... in the crys-tal lattice by applying the crystallographic two -fold axis. PfACMSD was reported to be a dimer, with subunits related by a dyad axis in the crystal, and a mixture of monomeric and ... shown assticks; the Zn2+ion and the solvent molecule bridging the metalcentre to the ligand are shown as magenta and cyan spheres,respectively.S. Garavaglia et al. Crystal structure of human...