Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... in obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in ... differentiation was initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum. Cells were fixed on day 4 of differentiati...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric structure of the enzyme. ... Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase. Biochemistry 35, 388 0– 388 5. 6. Leland,P.A.,Schu...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx
... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop ... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analys...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... deviates from the original position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table 1 and Fig. ... effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 (Fig. 3C). When the accessib...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... hydrolysis, resulting in an increase in intracellular sterol trafficking. It is unclear, then, whether the corresponding increase in pregnenolone pro- duction results from an increase in free sterol ... pregnenolone, including the effect of the steroid products on the yeast sterol synthesis pathway, acetylation of the product, availability of the substrate, electron fl...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
... loose binding of azide to the trinuclear copper center. As the hydrogen bond between the C-terminus and His140 is broken, and the stability of the trinuclear site is decreased, the binding of azide ... preventing binding of oxygen. We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the effect of the...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with the ATM-related kinase, ATR, and the ... activation of the S-phase checkpoint. The Mre11-bind- ing domain is responsible for binding to Mre11 during formation of the Mre11–Rad50–Nbs1 (MRN) complex. The AT...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot
... release restores the inward- facing state. The linker region of P-gp can be assumed to connect the C-terminal helix of subunit A (shown in red in Fig. 7) with the N-terminal elbow helix of sub- unit ... containing P-gp, the results could be affected by other proteins. In fact, it was reported that the linker region of P-gp interacts with other proteins such as RI...
Ngày tải lên: 29/03/2014, 23:20
Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the fibrin polymerization process pdf
... sequences in the N-terminal region of the fibrin Bb-chain, have been investigated. Peptides Bb12–26 and Bb26–46, but not Bb40–46, Bb19–26, and Bb26–36, proved to be specific inhibitors of fibrin polymerization. ... activity of synthetic peptides mimick- ing the various fragments of the N-terminal region of the fibrin Bb-chain was investigated. Two peptides, Bb12–26 and...
Ngày tải lên: 30/03/2014, 03:20
Báo cáo khoa học: Biological role of bacterial inclusion bodies: a model for amyloid aggregation potx
... in the target recombinant protein [22]. The distribution of side chains in the sequence, such as occurs in protein folding, plays a pivotal role in determining the conformational properties of ... problems in the development of the biotechnology industry. Over the last decade, the fine dissection of the quality control system in bacteria and the reco...
Ngày tải lên: 06/03/2014, 00:20