Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release docx

... et al. (Eur. J. Biochem. 271) Ó FEBS 2004 Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E 2 release Joanna E. Chivers 1 , Lisa M. Cambridge 1 , ... and RU486 (< 1 l M ) was without significant effect. Thus, two pharmacologically distinct mechanisms of glucocorticoid- dependent repression of pros...

Ngày tải lên: 07/03/2014, 16:20

... versions of these two isoforms, as well as of the Mxi1-WR isoform that lacks the SID, and shown to give rise to proteins of the expected size expressed at similar levels (Fig. 1A). Each of these ... graph shows the results of one representative experiment of a total of three experiments performed, each giving similar results. Distinct functions of Mxi1 protein isoforms C. Du...

Ngày tải lên: 18/02/2014, 16:20

... induction of Timp-1. For either PMA or TGF-b1 to induce Timp-1 expression, new protein synthesis is required, and the induction of AP-1 factors closely precedes that of Timp-1. The effects of the ... the expression of a protein(s) required for induction of the Timp-1 gene. Time course of TSA action upon PMA- and TGF-b1-induced Timp-1 expression The time course of inducti...

Ngày tải lên: 16/03/2014, 18:20

... structural position of the parsing tree, the predictive information quantity of lexical feature type is larger than that of part -of- speech feature type, and the predictive information quantity of part- of- speech ... information quantity, predictive information gain, predictive information redundancy and predictive information summation. Predictive Information Quantity (PIQ) );(...

Ngày tải lên: 20/02/2014, 18:20

... inhibitor for digestion of CII by HflB, than CIII [11]. Is this mode of antiproteolytic action of CIII a general mode of CIII activity, or does it apply only for CII? We examined the mode of the ... mode of action for kCIII would be independent of the HflB substrate. In this study, we tested the ability of CIII to protect r 32 from HflB digestion. The inhibition of HflB-me...

Ngày tải lên: 23/03/2014, 10:20

... mid-point of the unfolding profile monitored by CD (h 222 nm) and fluorescence (k emission for k excitation of 295 nm) over a dena- turant concentration range of 0–8 M for urea and 0–7 M for guanidinium ... geometry of the active site. The availability of crystal structures of TIMs from 21 sources and the large database of TIM sequences from various sources facilitate an ana...

Ngày tải lên: 18/02/2014, 11:20

... by ATP. Therefore, the antimicrobial activity of these two latter peptides may involve a different mechanism. The concept of a possible role for ATP in the mech- anism of action of H4-(86–100) ... The location of secondary structure in histone H4. Eur J Biochem 79, 535–548. 33 Park CB, Kim HS & Kim SC (1998) Mechanism of action of the antimicrobial peptide buforin II: bufo...

Ngày tải lên: 18/02/2014, 14:20

... or excess of kinetic energy (as a measure of temperature) and its effect on enzyme activity. Alternatively, we know of a number of examples of qualitative strategies, for example, when expression of distinctly ... existence of two LDH-A mRNAs of different lengths: short (a-isoform; mRNA a ldhÀa ¼ 1332 bp) and long (b-isoform; mRNA b ldhÀa ¼ 1550 bp). Sequence analysis of t...

Ngày tải lên: 19/02/2014, 02:20

... the membrane of cells. Inhibitory effects of VVA1 on the hemolytic and cytotoxic activity of VVA2 The effects of VVA1 on the hemolytic activity of VVA2 were studied by incubation of human red ... is required for the inhibitory effects of VVA1 on the pore-forming activity of VVA2, pull-down experi- ments were performed. As a preliminary experiment, we investigated the...

Ngày tải lên: 19/02/2014, 06:20

... or EGTA for 30 min and then incubated with VTA 3 for different incubation times before the measurement of cytosolic Ca 2+ . Preparation of giant liposomes Large unilamellar vesicles of asolectin ... used for excitation of Texas Red-labelled VtA 3 (filtered with a long pass filter < 560 nm). Optical sections of 1.8 lm through the centre of the spores or 4 lm for the liposo...

Ngày tải lên: 19/02/2014, 07:20