Báo cáo khoa học:The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks docx

... 2004 The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks Hermann-Georg Holzhu¨ tter Humboldt-University Berlin, Medical School (Charite ´ ), Institute ... minimum of the total flux. Insofar, the principle of maximal biomass production is a special case of the more general principle of flux minimization. It...

Ngày tải lên: 07/03/2014, 15:20

... join-preserving encoding of into iff: injectivity is an injection, zero preservation 2 iff , and join homomorphism , where they exist. Join-preserving encodings are automatically order- embeddings ... Generalized Encoding of Description Spaces and its Application to Typed Feature Structures Gerald Penn Department of Computer Science University of Toronto 10 King's Colle...

Ngày tải lên: 08/03/2014, 07:20

... form," a string of phonetic units. The derivation consists of a series of cycles. On each cycle, the ordered sequence of rules is ap- plied to every maximal string of units containing no internal ... well as differing in the degrees of vowel height, tone, and stress they allow. Therefore, the set of features must be allowed to vary from lan- guage to langua...

Ngày tải lên: 31/03/2014, 18:20

... RTB and the cytotoxicity of each of the resultant ricin variants was compared to wild-type ricin. Ricin R213A and ricin R213D were 12-fold and more than 2000- fold less cytotoxic than ricin, ... ricin R213A, j;andricin R213D, m.(B)ricin,d; ricin R258A, j, and ricin R258D, m;(C)ricin, d; ricin R48A, j. Fig. 2. Assessment of the N-glycosidase activity of RTA variants con- tain...

Ngày tải lên: 19/02/2014, 12:20

... Charniak and Johnson (2001) and split the corpus into main training data, held-out train- ing data and test data as follows: main training con- sisted of all sw[23]∗.dps files, held-out training con- sisted ... Model The intuition motivating the channel model design is that the words inserted into the reparandum are very closely related to those in the repair. Indeed, in our trai...

Ngày tải lên: 20/02/2014, 04:20

... FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B 1 and B 2 bradykinin receptors Alexander Faussner 1 , Alexandra Bauer 1 , Irina Kalatskaya 1 , ... As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin receptors A....

Ngày tải lên: 07/03/2014, 16:20

... one of the most studied neuropeptides of this group because of its potential importance in shrimp aquaculture. In penaeid shrimp, GIH is produced in the X-organs and stored in the sinus glands of ... analysis of the hemolymph and ovary total protein of dsRNA-injected females. (A) Hemolymph sample of NaCl ⁄ P i - injected and dsRNA-injected females. Lanes 1–3: NaC...

Ngày tải lên: 16/03/2014, 05:20

... when coupled to the tandem GAF domain of PDE10, and by cGMP when linked to the tandem GAF domain of PDE2, )5or)11. The bio- chemical properties of signalling by human tandem GAF domains to cyaB1 ... features exist in the N-ter- mini of GAF-domain-containing PDEs that might contribute to intramolecular signalling in a similar manner. Another point merits discussion. Irres...

Ngày tải lên: 16/03/2014, 06:20

... N-domain, only IC 50 values for inhib- itor binding to the N-domain can be obtained from the inhibition profile. Thus, affinity of the inhibitor for the mouse ACE C-domain cannot be determined using this ... mainly inhibit the activity of one active site, allowing the determination of the kinetic parameters of the other active site, free of inhibitor. For each species and each inh...

Ngày tải lên: 16/03/2014, 13:20

... position closer to E187, in order to minimize unfavourable interactions with the apolar side chain of F331. Thus, the increment in the pK a of E399, in addition to it being closer to E187, may have ... the catalytic proton donor. Thus, interactions between E399 and Y331 or R97 may be key elements in the determination of Sfbgly50 pH optimum. The role of arginine in...

Ngày tải lên: 23/03/2014, 15:21