Báo cáo khoa học: Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids docx

... syn- thase, phosphofructokinase 2, ceramide synthesis, glucose uptake, apoptosis, insulin receptor substrate 1, mammalian target of rapamycin kinase (mTOR), mitogen-activated protein kinase kinase 3, ... oxidation. Keywords: AMP-activated protein kinase; fatty acids; heart; insulin; protein phosphorylation. The AMP-activated protein kinase (AMPK) is a heterotri- meri...

Ngày tải lên: 07/03/2014, 15:20

... refolding of misfolded proteins [5–8] and remove protein aggregation [9–12]. Mechanisms of protein osmolyte interactions, the effect of osmolytes on protein stability, and how osmo- lytes correct protein ... leading to the preferential hydration of the protein domain is the driving force of protein stabiliza- tion or folding [3,4]. Furthermore, the effect of osmolyte...

Ngày tải lên: 07/03/2014, 00:20

... on the interaction between prealbumin, retinol-binding protein, and vitamin A. J Biol Chem 246, 44–49. 71 Bellovino D, Morimoto T, Tosetti F & Gaetani S (1996) Retinol binding protein and ... important role in a variety of physiological events and regulates nuclear factor k-B (NF-kB), mitogen activated protein kinase (MAPK), and Jun – N-ter- minal kinase (JUNK) signaling [1...

Ngày tải lên: 07/03/2014, 10:20

... differentiation and function of distinct cytokine-producing, effector T-cell populations. Abbreviations BTK, Bruton’s tyrosine kinase; IFN, interferon; IL, interleukin; iNKT, invariant natural killer ... Tec kinases contribute to human diseases involving distinct types of T-cell activation and cytokine production. In this minireview, we cover the roles of Itk and Rlk ⁄ Txk in T...

Ngày tải lên: 28/03/2014, 22:21

... DNA-binding domain that is presen t in many transcription factors including Kruppel, Hunchback and Antennapedia [14], as well as other DNA-binding proteins [28,29]. There are 11 repeatsof(S/T)PXXinmNARG2(seveninexon10),and six ... stretch of basic amino acids near the C-terminus of the protein (KKRKKIRR, amino acids 764–771 of the mouse sequence Ó FEBS 2004 NARG2, a novel nuclea...

Ngày tải lên: 23/03/2014, 13:20

... quantitation of microgram quantities of protein utilizing the principle of protein- dye binding. Anal Biochem 72, 248–254. 39 Sambrook J & Russell DW (2001) Molecular Cloning: A Laboratory Manual. ... been identified using a random insertional mutagenesis technique [3]. Several of these were proteins of unknown function, including an aldo-keto reductase (AKR). The role of th...

Ngày tải lên: 30/03/2014, 04:20

... actor (EGF), which bind to dedicated receptors. Upon EGF binding, its receptor (EGFR) dimerizes, leading to autophosphoryla- tion of tyrosine residues on the cytoplasmic domain of the receptor, ... signal-regulated kinase; ERK-PP, doubly phosphorylated ERK; Grb2, growth factor receptor binding protein 2; IP3, inositol triphosphate; MAPK, mitogen-activated pro- tein kinase; MEK, MA...

Ngày tải lên: 19/02/2014, 16:20

... reduction of the cytotoxicity of S23906-1 is attributed to the reduced formation of lethal drug–DNA covalent complexes in cells. Treatment of the cells with buthionine sulfoximine, an inhibitor of GSH ... reduction of cytotoxicity by a factor of about six. In this case, the IC 50 value of 4.2 l M determined with mechlorethamine alone increased to 24.8 l M in the pr...

Ngày tải lên: 20/02/2014, 11:20

... FEBS Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function to activate plasma proteins that ... function of the cytokine Spa ¨ tzle-1 is conserved in the immune system of a lepidopteran insect, suggesting that a cytokine-activated Toll path- way is an ancient feature of...

Ngày tải lên: 06/03/2014, 09:22

... domain B (indicated in Fig. 2). This inserted domain participates in substrate binding and is rather variable. It is considered to play a role in determining the enzyme specificity [41]. The end of ... The removal of Ca-I was shown to promote proteolysis [43,44]. Ca-I is co-ordinated by the side chains of Asp280 and Ser222 at the beginning and end of domain B as well as by th...

Ngày tải lên: 08/03/2014, 02:20