Báo cáo khóa học: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells potx
Báo cáo khóa học: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells potx
... 2003 Nucleolin is a cell surface lactoferrin -binding site (Eur. J. Biochem. 271) 317 Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells Dominique ... the iron -binding hTf had no effect. On the other hand, bLf inhibited the binding of HB-19 to cells. In accordance with the involvement of both lobes of hLf in the mechanism of Lf binding to nucleolin, ... that both heparan sulfates and nucleolin are involved in the endocytosis of hLf into CHOK1 cells. Fig. 7. Binding of human lactoferrin (hLf) to nucleolin expressed onMDA-MB-231 cells. The figure...
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Báo cáo khoa học: "DICTIONARY ORGANIZATION FOR MACHINE TRANSLATION: THE EXPERIENCE AND IMPLICATIONS OF THEUMIST JAPANESE PROJECT" ppt
... implemented, and the form of its surface presentation is also being refined. Foundations in linguistic theory We are committed to active recognition of the mutual benefit of machine translation and ... enabling the user to extend the available working vocabulary without bilingual knowledge. The dictionaries, the user, and the system The dictionary creation routines, whether in monolingual ... to the design of the parser. The dictionaries and the system The program form dictionaries factor out different types of information to be invoked at different stages in parsing and interpretation...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... within the same cell. Furthermore, in cells expressing either the double or single mutants, wetended to see a decrease in the number of cells with the ability to reduce transferrin binding compared ... that cells expressing wild-typeHFE displayed a striking decrease in cell -surface bind-ing of transferrin, and that little or no reduction in transferrin binding was observed in cells expressing ... HEK293T cells to express either the wild-type or mutant proteins, and incubated the cells in the presence or absence of tunicamycin. Drugtreatments resulted in the accumulation of forms of the mutant...
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Báo cáo khoa học: Surface exposed amino acid differences between mesophilic and thermophilic phosphoribosyl diphosphate synthase ppt
... central intermediate in the de novo and salvagebiosynthesis of pyrimidine, purine and pyridine nucleotidesas well as in the biosynthesis of the amino acids histidine and tryptophan [1,2]. In addition, ... activity obtained in the absence of thesenucleotides. The activity in the presence of 5.0 mMUTPwas only 20% of that in the absence of UTP, indicatingsignificant inhibition. Only ADP and GDP showedsignificant ... Cu2+. The activity in the presence of Mn2+was about 30% of the activity determinedinthepresenceofMg2+, while the activity in the presence of Zn2+,Cd2+or Cu2+was only 5–10% of the activitydetermined...
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Báo cáo khoa học: Tryptophan 243 affects interprotein contacts, cofactor binding and stability in D-amino acid oxidase from Rhodotorula gracilis ppt
... a-helix containing the peroxi-somal targeting signal) to the bab motif, known as the dinucleotide -binding domain [2], and on the other sideto the long loop following the b-strand I7 containingTrp243 ... titrating the apoprotein with increasing amounts of FAD and following the decrease in protein fluorescence: a Kdvalue of 0.37 and 0.035 lm of the apoprotein–FADcomplex was obtained for the W243I ... apoprotein with FADBecause of the weaker binding of the FAD cofactor to the apoprotein of the W243 mutants, we studied the kinetics of reconstitution of the apoprotein–FAD com-plexes under pseudo-first-order...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... located in independent domains(a b-domain for the N-terminal cluster and ana-domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc-tured and ... First, the metal binding is thermodynamically relatively stable, with the following order Cu(I)>Cd(II)>Zn(II). The clusterstructure raises the possibility of a cooperative binding of the ... asa result of the formation of disulfide bridges [2]. Sec-ond, in contrast to the high thermodynamic stability, the binding is kinetically labile, allowing rapid intra-molecular and intermolecular...
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Tài liệu Báo cáo khoa học: Four divergent Arabidopsis ethylene-responsive element-binding factor domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference pptx
... most of the AtERFs exhibitedsimilar stability in binding to either the GCC or the DRE motif. The most remarkable feature arising from the competition binding assay was the consistency of the binding ... Competition binding assay of the ERF–DNA complex. The binding complex of the ERFs and their binding DNAs were incu-bated together with 0, 0.001, 0.01, 0.1, 1.0 and 10 lg poly[dA-dT].poly[dA-dT] in a ... Effect of single base substitutions on the relative binding free energy change (DDG) in the binding of the four ERF domainsto the DRE motif. The DNA sequence shown at the bottom is the DRE motif in...
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Tài liệu Báo cáo khoa học: Tet repressor mutants with altered effector binding and allostery docx
... consisting of helices a2 and a3 at the N-termi-nus. The core domain (a5toa10) contains the tc bind-ing pocket and the dimerization motif. Both domainsare connected by helix a4, and their interface ... affinities and positive cooperativity. Thus, mutations in this interface can in uence DNA binding as well as effector binding, albeit both ligand binding sites are not in direct contact to these altered ... known so far. The DNAfragments containing the randomized codons 14–25(C-terminal part of helix a1 and the following loop) and 93–102 (helix a6 and the b-turns N-terminal and C-terminal of a6) as...
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Tài liệu Báo cáo khoa học: "Collecting a Why-question corpus for development and evaluation of an automatic QA-system" pdf
... answers each. The total cost of producing the corpus was about $350, consisting of $310 paid in workers rewards and $40 in Mechanical Turk fees,including all the trials conducted during the devel-opment ... documents). The source of Wik-iXML is the English part of the Wikipedia XMLCorpus by Denoyer and Gallinari (2006). In the original data some of the HTML-structures like lists and tables occurred within ... approvalrate of 80%, a prerequisite for both the QRepHITs and the QAHITs.A total of 2355 workers took the test, and 1571(67%) of them passed it, thus becoming our avail-able worker pool. However, in the...
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Tài liệu Báo cáo khoa học: "Organizing Encyclopedic Knowledge based on the Web and its Application to Question Answering" ppt
... which do not contain an in- put keyword. Since the extraction module (see Sec-tion 2.3) analyzes the usage of the input term in re-trieved pages, pages not containing the term are of nouse for ... FDDI, d) token ring In the autumn of 1999, out of 80 questions, the num-ber of the first and second types were 22 and 18, re-spectively.4.3 Implementing a QA systemFor the first type of question, ... similar to the description.For the second type of question, human examineeswould search their knowledge base for the description of each of four candidate terms. Then they wouldchoose the candidate...
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Từ khóa: báo cáo khoa họcbáo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ