... favour of the existence of a long- term regulation of MLC2 phosphorylation, besides the short-term regulation that is dependent on calcium released during contraction. Long-term regulation means ... decrease of mass) when compared with the corresponding muscles of the control animals (CONT) or with the muscles of the controlateral unoperated limb (CODE). The distri...
Ngày tải lên: 23/03/2014, 11:20
... metabolism. The functional association was further aided by integration of protein interaction data with data on gene expression, localization, func- tion, evolutionary conservation, protein structure ... temporal patterns of Mef2 target gene regulation. Although most of the reported transcription networks based on chip -on- chip data are static, Fur- long described one of th...
Ngày tải lên: 30/03/2014, 09:20
Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... shielding most of the upper surface of the b-sheet from the environment. Upon dimerization, exten- sive contacts are formed between the subunits so that the b-sheet becomes extended to form a continuous 10-stranded ... measurements of WT MS2 as a function of urea concentration. To verify the dissociation and denaturation processes, we measured the light scattering of...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... of the purified dioxygenase to the reaction mixture with a large excess of the purified enzyme reported here to avoid the formation of 2,5-pyridinedicarboxylic acid from 2-amino-5-carboxy- muconic ... to 2,5-pyridinedicarboxylic acid based on the wavelength [10]. Purification and properties of the purified enzyme The activity of the enzyme present in the crude extrac...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... at the end of the titration, even after addition of excess Cu(I), some species still retained Zn(II) ions. The discussion of the Cu(I) coordination behavior becomes more complex in view of the ... under the same conditions as described for the holo-forms, with the following exceptions for releasing Zn(II) ions but not Cu(I) ions from the complexes: the liquid carri...
Ngày tải lên: 07/03/2014, 02:20
Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... chordates possess only one syndecan, which is essential for neuronal development and axon guidance [1,2]. All cells express at least one member of the syndecan family [3], with the exception of erythrocytes. ... whereas others partners are the actin-associated protein a-acti- nin as well as syndesmos, about whose function rather little is known [10]. The transmembrane domain of...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster ppt
... influence on the yield of GDP-Fuc. Furthermore, reduced conversion of the intermediate was observed in the absence of dithiothreitol. On the basis of these data, we did not alter the assay mixture composition ... than the con- version of GDP-Man into products in the presence of both enzymes (e.g. with Drosophila GMD alone the conversion of GDP-Man into the...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... compute a linear regression of Q-level across 12 months, conduct a hypothesis test (with the null hypothesis being the slope of the regression equal to zero), and report the P -value for two-tailed ... not on clustering but on understanding the expression of intent. 3 Method We address the main thesis of the work by retrospec- tively studying queries issued to a sear...
Ngày tải lên: 17/03/2014, 00:20
Báo cáo khoa học: "Lexicalization in Crosslinguistic Probabilistic Parsing: The Case of French" potx
... The effect of this decision needs to be investigated in future work. XP X COORD C XP X XP X C XP X XP X C X Figure 3: Coordination in the FTB: before (left) and after transformation (middle); ... shows that the poor POS tagging performed by BitPar is one of the reasons of the poor performance of the lexicalized models. The impact of perfect tagging is less...
Ngày tải lên: 17/03/2014, 05:20
Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx
... hydrogen bond interactions with the backbones of A299 (7.46) and G51, which stabilize the distorted con- formation of TM7 around the NPxxY motif. The same crystal structure contains one water ... Because of the stronger effect of Gta- HAA in shifting the altered conformation of G51V, we focused on this mutant for the double mutant studies described in the following...
Ngày tải lên: 22/03/2014, 16:20