Báo cáo khoa học: SHP-1 dephosphorylates 3BP2 and potentiall

Báo cáo khoa học: SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling ppt

... response to anti-CD3 stimulation in 3BP2- transfected cells. Furthermore, SHP-1 also inhibited the consti- tutive NFAT activation in 3BP2- transfected cells but not the basal NFAT activity in the cells ... NFAT activation. Jurkat T cells were cotransfected with the NFAT-luciferase reporter gene and empty vector, 3BP2 myc and SHP-1 or its mutants as indicated. Twenty hours after...

Ngày tải lên : 07/03/2014, 12:20

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341
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Báo cáo khoa học: Contributions of host and symbiont pigments to the coloration of reef corals pptx

... Biomeda, Foster City, USA) did not show cross-reactivity with the fluorescent pigments from the coral extracts (data not shown). Therefore, the fluorescent color of this coral cannot be attributed to a ... ectodermal tissue and contribute up to 7.0% of the total soluble cellular proteins in these species. Distinct spatial distributions of green and cyan fluorescent proteins were observed for...

Ngày tải lên : 16/03/2014, 11:20

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Báo cáo khoa học: Disruption of structural and functional integrity of a2-macroglobulin by cathepsin E pptx

... activities via its interaction with various target proteins, such as the control of the activity of proteinases, the regulation of the activities of numerous cytokines and growth factors, and the enhancement ... associated with cathepsin E below pH 5.0 and rapidly cleaved it at a speciﬁc site distinct from the bait region, thereby losing its structural and functional integrity. Materi...

Ngày tải lên : 23/03/2014, 21:20

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Báo cáo khoa học: HIV-1 gp41 and gp160 are hyperthermostable proteins in a mesophilic environment ppt

... functional trimers. In contrast, Weis- senhorn et al. [8] state that the trimeric structure of gp41 is too stable to be disrupted by peptide binding and propose that peptides exert their activity ... fusion intermediate of gp41. It was thus attempted to generate recombinant gp41 mutants that resemble this intermediate state. Ways were explored to stabilize the interaction between helices N,...

Ngày tải lên : 30/03/2014, 13:20

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Báo cáo khoa học: Oligomannose-coated liposomes efﬁciently induce human T-cell leukemia virus-1-speciﬁc cytotoxic T lymphocytes without adjuvant doc

... prevent the relapse of ATL in postallogeneic stem cell transplantation patients. The expression of Tax by the host cell targets them for attack by CTL, resulting in the elimination of the infected ... unpulsed T2 -A2 cells as target cells, speciﬁc cytotoxic activity was evaluated by FCM assay of cell- mediated cytotoxicity. All tests were carried out in triplicate at effector : target r...

Ngày tải lên : 14/03/2014, 23:20

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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... enzyme that can sense and respond to the nutritional environment. The major challenge to understanding the role of CPT1c is to determine its enzymatic activity and regulation and how this ultimately ... cytokines, interact with their cognate receptors on neurons within the CNS that project to higher brain centers and to peripheral tissues to affect energy intake and expendi- ture. I...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... pantoate. It is important to note that, at the level of sensitivity and resolution available for these studies, pantoate was not found to bind to any other site on the protein, leading us to conclude ... site, and that ATP displaces this molecule of pantoate. b-Alanine and pantothenate did not bind nPS under the experimental conditions. Attempts to study the binding of ATP alone to the...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... sense, 5¢-CCGAGATCTGGCTTTTACTTAAACCG-3¢; IL6R antisense, 5¢-CAGGAATTCACTTGCTCTGTCACCC-3¢; GAPDH sense, 5¢-GCGAATTCCGTGTCCCCACTGCC AACGTGTC-3¢; GAPDH antisense, 5¢-GCTACTCGAGT TACTCCTTGGAGGCCATGTGG-3¢. The ... expressed as the means ± standard devia- tion (SD) and statistical analysis utilized a two-tailed Stu- dent’s t- test. Statistical signiﬁcance was set at P £ 0.05. Acknowledgements We...

Ngày tải lên : 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

... factors such as hypertension, visceral adiposity, smoking and alcohol consumption contributed to ED in men with T2 DM. The authors suggested that ED is associated with low BAT and FT, but not TT, ... different anthropo- metrical measurements to assess obesity and this, in addition to the age of the cohort being studied, has inﬂuenced the strength of the correlation between ED and obe...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf

... result in subop- timal orientation of the P1 Arg residue. The magnitude of the effects of the G372(223)A mutation is slightly substrate-dependent. The fact that the relative reduc- tion in activity ... facilitate insertion of the N-terminal tail into the activation pocket. Hence the presence of TF stabilizes the two hydrogen bonds, i.e. it indirectly supports the substrate binding cleft and...

Ngày tải lên : 18/02/2014, 08:20

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