Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx

... while the OS-fitness was close to 1. Relationship between antigen binding and V H ⁄ V L interaction The relationship between the indexes of antigen-bind- ing affinity and V H ⁄ V L interaction strength ... correlation between the antigen- binding affinity and the V H ⁄ V L interaction, especially in the presence of a set of particular V L residue...

Ngày tải lên: 07/03/2014, 12:20

... example, in the case of question Q209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol- cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop- erties of lava, the fol...

Ngày tải lên: 08/03/2014, 05:20

... selective inhibitor of Glc6P hydrolysis [31], for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes ... control of glycolysis and glycogen synthesis by glucokinase overexpres- sion. The validity of S4048 for testing the role of Glc6P was support...

Ngày tải lên: 16/03/2014, 14:20

... tight binding affinity was demonstrated towards lauric acid, resulting in the synthesis of mainly x-1 hydroxylated lauric acid, suggesting a role in the lipid oxidative metabolism. Interestingly, the ... required for breaking the plant’s defence but, on the other hand, alkanes serve as nutritional input during the initial col- onization steps. Insect cuticle consists of...

Ngày tải lên: 22/03/2014, 16:21

... Nuijens Pharming, Archimedesweg, Leiden, the Netherlands Lactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linked glycosylation in protection of ... herein further elucidate the role of N-linked glycosylation in the protection of lactofer- rin against tryptic proteolysis. It appeared that glycosylation at...

Ngày tải lên: 30/03/2014, 13:20

... (rotation angle ‘r’) and variation of the inclination (inclination angle ‘i’) with respect to the plane of the membrane (parallel to the xy plane). Cter and Nter are the C-terminal and N-terminal structural ... onto the axis z, and (b) to conserve the minimal distance between protein and membrane at 3.5 A ˚ . The EIE, i.e., the electrostatic contribution to th...

Ngày tải lên: 19/02/2014, 06:20

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesi- cles. Then, the capsid uses these intra-endosomal ... studies in our group demonstrated the involvement of the in ammatory kinase JNK and endoplasmic reticulum (ER) stress as events involved in both sensing and relayi...

Ngày tải lên: 19/02/2014, 07:20

... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... and the effect of the absence of intact complex I, but the results are too preliminary in this regard. Heterologous expression of the ESSS-HA subunit The loca...

Ngày tải lên: 19/02/2014, 16:20

... involved in the regulation of the stability and trafficking of GAT1. It has been reported that a variety of molecular chaperones and folding enzymes assist the folding of newly synthesized proteins in ... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain furth...

Ngày tải lên: 19/02/2014, 17:20

... further investigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directed mutagenesis of the FRPG ⁄ SVVV site and evaluated hybrid mucins in which the ... the role of this domain in the processing of membrane-tethered mucins. The mech- anism by which the heavily glycosylated portion of these molecules is rel...

Ngày tải lên: 19/02/2014, 18:20