Báo cáo khoa học: The enzyme-binding region of human GM2-activator protein pdf

... [36]. A role of the cytoplasmic tail of membrane-spanning proteins in protein protein interactions has also been proved, e.g. the case of the association between the N-terminal region of the membrane-bound ... that most of the RIP substrates, including Jagged-1, actu- ally fall in the left-hand side of the plot (natively unfolded proteins). All the proteins t...

Ngày tải lên: 18/02/2014, 16:20

... for the last four residues at the C-terminus. The stereochemistry of the model has been assessed using the program procheck [23]. Ninety per cent of the residues fall in the most favoured regions ... movement of the two protein residues upon ligand binding. The dotted line highlights the hydrogen bond established between the DHAP phosphate moiety and Trp191 in t...

Ngày tải lên: 18/02/2014, 06:20

... antigenically distinct [10,11]. The A domain of ClfA and FnBPA bind Fg at the C-terminus of the c-chain [7]. The interaction between the A domain of ClfA and the c-chain of Fg has been studied in detail. ... residues P336 and Y338 of ClfA. One of the objectives of this study was to determine the mechanism of Fg binding by the A domain of FnBPB. Located dist...

Ngày tải lên: 06/03/2014, 00:20

... tradition of our own These are not parsed as a result of the rigid assumptions about the ordering of arguments and modifiers built into the grammar. These need to be relaxed on the basis of some theory ... (modulo the inclusion of coordination and exclusion of formulae and foreign phrases) because they are based entirely on the literal form of the tags in th...

Ngày tải lên: 09/03/2014, 01:20

... inform the hearer of the relevant properties of the shirt, assum- ing the hearer has some domain knowledge about T- shirts. However, if the hearer has this domain knowledge, the use of utterance ... If the attribute values and classifications used in the description are members of a taxonomy, then they can be realized at different levels of specificity. For e...

Ngày tải lên: 17/03/2014, 20:20

... described in the liter- ature. Further complicating the field of Cyp biology is the fact that many of the 17 Cyps annotated in the human genome have not been thoroughly studied in terms of either enzymatic ... Acceleration of the cis–trans isomerization of the peptide results in the collapse of these resonances into a single set of peaks. (D) Binding, but not is...

Ngày tải lên: 23/03/2014, 07:20

... with j-casein in human milk [12]. The molecular cloning and sequencing of mRNA transcripts revealed the presence of three forms of a s1 -casein in human milk [13,14]. In the present study, we report the phosphorylation ... indicating the presence of a single phosphorylation in the peptide. Furthermore, the Fig. 2. Localization of phosphorylations in human a s1 -c...

Ngày tải lên: 23/03/2014, 21:20

... informa- tion such as the metabolic activity of the lactate pool, the intracellular location of this pool and the relative rates of glycolysis and oxidative metabolism in these tumours [49–51]. Paediatric ... monitoring of brain tumour metabolites The use of NMR spectroscopy to profile metabolites in tumour cells and tissues has been applied to a wide range of human tum...

Ngày tải lên: 23/03/2014, 09:21

... phase, respectively; c L is the lipidic molar volume [26] and [L] is the concentration of the lipid accessible to the peptide (the outer leaflet of the bilayer). In the presence of POPC LUV, for MPRP-C, MPRP-S ... may reach the point where all of the membrane is homoge- neous. The MPRP-C is insensitive to the cholesterol content in the membrane, which is in agree...

Ngày tải lên: 23/03/2014, 07:20

... intravenous lines). The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation. As a consequence, the clinical relevance of the predefined ... for other infections, and the absence of radiological signs of pulmonary congestion might have resulted in another fluid therapy regimen. We did not sco...

Ngày tải lên: 25/10/2012, 10:39