Báo cáo khoa học: Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome docx

... during embryogenesis and there- fore may not perform a function equivalent to mam- malian FABP1 during zebrafish embryogenesis. The distinct patterns of expression for the fabp1b (in the intestine) ... pattern of expression for the fabp1a, fabp1b and fabp10 genes in zebrafish, suggesting a division of func- tion for these orthogolous and paralog...

Ngày tải lên: 07/03/2014, 12:20

... directly involved in ligand binding, presumably abolishing the interaction with signaling partners. The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce ... disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has bee...

Ngày tải lên: 14/02/2014, 18:20

... mechanism of rhodamine dyes, agents allowing the enhanced uptake of rhodamine dyes inhibited the efflux of these dyes from the cells. The efflux of rhodamine 123 and TMRM was inhib- ited by NBD-Cl and ... accumulation of dyes, and probably certain drugs, in the cytoplasm. On the other hand, high-affinity binding of these agents to intracellular receptors over-...

Ngày tải lên: 18/02/2014, 13:20

... probability of formation of the cisplatin IACs within the p53DBSs due to the occurrence of the GG, AG and ⁄ or GNG motifs, the stronger the inhibition of the p53 sequence-specific DNA binding to these ... DNA cis-platination on sequence- specific DNA binding of p73 proteins We tested the in uence of DNA modification with cisplatin on the binding of two p73 is...

Ngày tải lên: 19/02/2014, 05:20

... This may indicate a role for the C-terminal helix of Bax in the formation of large pores, although it may also be due to the in uence of this domain on the efficiency of membrane insertion. The ... hairpin found in the core of water-soluble folds of these proteins has been reported to be the pore- forming domain. Here we show that peptides including any...

Ngày tải lên: 19/02/2014, 07:20

... to the formation of cavities, one in the hydrophobic core (M88V) and the other in the protein–RNA interaction (T45S), decrease the stability of the capsid. Our findings illuminate the role of ... different from those of other simple icosahedral viruses [13]. The main chain of the protein subunit folds into a five stranded antiparallel b-sheet (strands bC–bG) fa...

Ngày tải lên: 19/02/2014, 12:20

... Le a determinant. As the C 3a ion is at m/z 690, this excludes the possibility of the other Fuc being at the Gal next to the subterminal GlcNAc. The position of the second Fuc 3-linked to the internal ... function. One of the early demonstrations of the role of carbo- hydrates in recognition was binding of the in uenza virus to red blood cells via sialic a...

Ngày tải lên: 19/02/2014, 12:20

... that the molecular mechanism of ArgEE in preventing thermal inactivation and aggregation is different from that of Arg. Thermal unfolding profile of proteins in the presence of ArgEE In order to investigate ... more of the enzymes retained the active form after heat treatment at 98 °C for 10 min in the presence of 100 m M ArgEE at pH 6.5; under the same cond...

Ngày tải lên: 19/02/2014, 16:20

... merits of the two models. Instead of parse trees, our model intro- duces linguistic information in the form of chunks, so it does not need to care the internal structures and the roles in the main ... the tree-to- string model. The two models differ in the form of rules and the way of estimating rule probabilities. While for decoding, we employ the sa...

Ngày tải lên: 19/02/2014, 19:20

... trans interactions in favor of the latter. An increase in the trans inter- action results in an increase in the level of the functional Abd-B protein. Continuous lines represent the DNA of homologous ... difference in the tim- ing of somatic pairing perhaps reflects the difference between the complexities of the regulation of the two systems: a longer...

Ngày tải lên: 20/02/2014, 01:20