Báo cáo khoa học: Isoquinoline-1,3,4-trione and its derivatives attenuate b-amyloid-induced apoptosis of neuronal cells pdf

... considered as cells in the early stages of apoptosis. Cells distinguished by their ability to take up both FITC-Annexin V and PI were con- sidered as cells in the later stages of apoptosis. Live cells were ... IFN-c and harvested after 72 h of culture. IFN-c induced an increased percentage of cells in the G0 ⁄ G1 and a corresponding decrease of cells in the S an...

Ngày tải lên: 29/03/2014, 22:21

... PMNL and MM6. Results Free cholesterol and its anionic derivatives inhibit cellular 5-LO product formation We determined the effect of free cholesterol, CS, CP and CA on LT production in whole cells. ... containing AA and differ- ent concentrations of CS. CS in a concentration range of 10–100 lgÆmL )1 inhibited the production of LTs and 5-HETE (Fig. 6). Fig. 2. Cumulati...

Ngày tải lên: 30/03/2014, 11:20

... of methods to quantify the extent of differences and similarities between languages. For example, Fusco (1990) studies translations between Spanish and Italian and con- siders the impact of ... general effects of the process of translation that are independent of source lan- guage. Using a series of text categorization experiments, we show that both these effects exi...

Ngày tải lên: 07/03/2014, 22:20

... receptor and Grb7. A role for two of its binding domains, PIR and SH2. Oncogene 19, 2052– 2059. 36 Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) Cloning and characterization of GRB14, ... inhibitor of insulin signaling. Consistent with this observation, overexpression of Grb14 in CHO-IR cells impairs Akt and ERK insulin signaling pathways and inhibits distal...

Ngày tải lên: 18/02/2014, 18:20

... the activation energy of the enzyme-catalyzed reaction induced by the allosteric ligand and not by changes in the extent to which the binding of allosteric ligand modifies the affinity of enzyme for substrate. ... combination of low food availability and low environmental temperatures is hibernation [1–3]. The mammalian hibernator aban- dons homeothermy and allows body temperature...

Ngày tải lên: 19/02/2014, 16:20

... ERB4061-PL-950200 and by grants PB96-1446 and BIO2000-1459 of the Spanish Ministry of Science and Technology. The Oxford Centre for Molecular Sciences is funded by BBSRC, EPSRC and MRC. The research of CMD ... the equilibrium constant of unfolding and DG U is the change in the standard Gibbs energy of unfolding. The fractions of N and U, relative to the total concentra...

Ngày tải lên: 21/02/2014, 03:20

... of handling and studying IBs. The development of methods to con- trol and monitor the process of aggregation allows for the production of aggregated proteins endowed with residual structure and ... Raman (micro)spectroscopy could offer advantages still Fig. 4. FTIR analysis of the aggregation of a recombinant protein in E. coli. (A) Second derivatives of the FTIR absorpt...

Ngày tải lên: 06/03/2014, 00:20

... bigrams and trigrams of words and POS tags in the candidate sentence. • Bigrams and trigrams of words and POS tags in the original sentence in combination with their binary labels in the candidate ... difference of the compression ra- tio of the candidate sentence with that of the first ranked candidate. This is because we try to avoid a very large or small compression ra- ti...

Ngày tải lên: 07/03/2014, 18:20

... coverage of both languages using a roman alphabet and lan- guages using other alphabets, the development of lexical resources must include mechanisms for handling words which do not have standard ... of elements that can be described as consonants (including three consonant clusters "zh", "ch" and "sh") and vowels which consist of monothongs,...

Ngày tải lên: 08/03/2014, 06:20

... consists of a combination of automatically generated outputs oF the scene analysis processes (insofar as this is presently possible) and a number of manual augmen- tations. The length in time of ... an object of the class of vehicles, and therefore be a possible candidate to fill ~ the agent role of the verb 'to stop', can be 190 verified because of...

Ngày tải lên: 24/03/2014, 05:21