Báo cáo khoa học: Interactions between metals and a-synuclein ) function or artefact? pptx

... MINIREVIEW Interactions between metals and a-synuclein ) function or artefact? David R. Brown Department of Biology and Biochemistry, University of Bath, UK Introduction Advances ... proteins that undergo either abnormal conformational changes or whose metabolism is somehow modified. Links between Alzheimer’s disease (AD) and amyloid-b (Ab) Creutzfeldt–Jakob disease...

Ngày tải lên: 07/03/2014, 10:20

... lgÆmL )1 ); for BMJ71, tetracycline (5 lgÆmL )1 ); for JRS4 and JRS145, streptomycin (100 lgÆmL )1 )andfor JRS145/pLZM6 and the various M5 deletion constructs, spectinomycin (100 lgÆmL )1 )wasused. Proteins, ... USA) at 37 °C overnight. Appropriate antibiotics were added to the culture medium when required: for BM27.6, erythromycin (1 lgÆmL )1 ); for MC25 and 9...

Ngày tải lên: 20/02/2014, 11:20

... coenzyme. The K m values for AdoCbi and Ado- Cbi-GDP were 26 ± 8 and 75 ± 28 lm, respectively, and the k cat values were (9.8 ± 1. 0) · 10 )3 Æs )1 and (4.5 ± 0. 8) · 10 )3 Æs )1 , respectively. In ... straightforward, separating AdoCbi and AdoCbi-GDP directly without further modification. In contrast, the reactant and prod- uct, AdoCbi and AdoCbi-GDP, were a...

Ngày tải lên: 07/03/2014, 04:20

... 200 m sodium orthovana- date, 1 mm PMSF, 3 lgÆmL )1 protease inhibitor cocktail). The samples were vigorously vortexed for 15 s, kept on ice 20 min and centrifuged at 20 000 g for 20 min at 4 ... SH2 domain. (A) Stomach cancer tissue (C) and normal stomach tissue (N) were obtained from cancer patients in a local hospital (Dongguk University Pohang Hospital) and stored at )7 0 °C...

Ngày tải lên: 07/03/2014, 12:20

... Science Stanford University Stanford, CA 94305, US surabhi@cs.stanford.edu Matthew Purver Center for the Study of Language and Information Stanford University Stanford, CA 94305, US mpurver@stanford.edu Dan ... NBCH-D-03-001 0) and ONR (MURI award N00014051038 8). The authors also thank John Niekrasz for annotating our test data. 1 (1, 2) are taken from the ICSI Meeting Corpus (Sh...

Ngày tải lên: 08/03/2014, 03:20

... Coverage (IC): S2 and S9; Informative Relevance (IRV): S3 and S8; and Informative Redundancy (IRD): S4 and S7. 4 Results 4.1 Correlation between Human Evaluation and Original ROUGE Score Similar ... words or more mean- ingful semantic units, for example, ROUGE (Lin, 200 4), factoid analysis (Teufel and Halteren, 200 4), pyramid method (Nenkova and Passonneau, 200 4),...

Ngày tải lên: 17/03/2014, 02:20

... near-UV and Soret regions (250–320 nm and 320–470 nm, respectively) for iron(II)- HbI and iron(II)-HbIV at both pHs and in air are shown in Figs 1 and 2. In the range 250–320 nm (Fig. 1), CD spectra are ... (B), met-HbIV (C) and met-HbI (D) in 50 m M Tris/HCl, pH 7.8, (solid line) and 50 n M Bis/Tris, pH 6.0 (broken line). Temperature ¼ 6 °C. Fig. 2. Soret CD spectra of iron(I...

Ngày tải lên: 23/03/2014, 12:20

... purposes, based on form and function rather than on word-for-word correspondence. IN HIS "A Preliminary Study of Russian", 1 Kenneth E. Harper states that a "word-for-word translation ... sentences contained an imper- sonal, or understood, subject; 24 sentences contained no verb .) The position of subject be- fore verb (normal English word order) thus ap- pea...

Ngày tải lên: 19/02/2014, 19:20

... (RXR) (partial) [157] Collembola Folsomia candida USP (RXR) (partial) [157] Myriapoda Lithobius forficatus USP (RXR) (partial) [157] Urochordata Polyandrocarpa misakiensis USP (RXR) (partial) [157] Trichoptera ... retinoic acid receptor; ROR, retinoid-related orphan receptor; RXR, retinoid X receptor; SMRT, silencing mediator for retinoic and thyroid hormone receptor; SMRTER, SMRT EcR-cofact...

Ngày tải lên: 23/03/2014, 04:20

... residues are important for the interaction between v-KIND and MAP2. (A) Alignment of the KIND2-1 region in human, mouse and Gallus (top) and the corresponding mouse v-KIND KIND1, Spir-2 KIND and PTPN13 ... (PTPN13, or PTP-BL ⁄ PTP-BAS) [6,7], FERM and PDZ-domain-containing 2 (FRMPD 2) [8] and Ras guanine exchange factor (RasGEF) very- KIND (v-KIND, or kinase noncatalytic...

Ngày tải lên: 14/02/2014, 19:20