Báo cáo khoa học: Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils ppt
Báo cáo khoa học: Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils ppt
... 3765
MINIREVIEW
Branched chain mechanism of polymerization and
ultrastructure of prion protein amyloid fibrils
Ilia V. Baskakov
1,2
1 Medical Biotechnology Center, University of Maryland Biotechnology ... the mechanisms of polymerization for
several amyloidogenic proteins and peptides linked to conformational dis-
orders and solving their fibrillar 3D structu...
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... the upregulation of GnT-III. In fact, the results of
several studies suggest that E-cadherin can induce
ligand-independent activation of EGFR and subse-
quent activation of Rac1 and MAP kinase, ... and evidence for gain- and loss-
of- functions of target proteins for glycosyltransferases
involved in N-glycan biosynthesis: their pivotal roles in
growth and development, can...
Báo cáo khoa học: Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2a receptor mediated activation of MEK⁄ ERK-CREB cascade doc
... production of PGF
2a
and
PGE
2
. An FP receptor antagonist and each inhibitor for MEK and COX-2
suppressed the PGF
2a
-derived induction of synthesis of these PGs. Further-
more, promoter-luciferase and ... alpha
from prostaglandin H2 and D2. Purification and prop-
erties of prostaglandin F synthetase from bovine lung.
J Biol Chem 260, 7035–7041.
14 Fujimori K, Ueno T &...
Báo cáo khoa học: An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain docx
... ⁄ PAGE (D1) and wes-
tern blot analysis of the purified 13cIMH. Equal amount of proteins
(25 lg) and 0.5 lg of eluted protein were resolved by 8%
SDS ⁄ PAGE. T, lysed total cellular protein; C, ... Localization of zebrafish 13cIMH in
the brain and eye. (A) RT-PCR analysis of
RPE65 and 13cIMH using RNA from the
zebrafish eye and brain. RT-PCR was
performed in the absence ()...
Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf
... the help of the CDPro software
package, which contains three commonly used programs:
selcon3, contin ⁄ ll and cdsstr [42,43]. This software
allows the use of different reference sets of proteins, ... and NMR
structure of human Bcl-xL, an inhibitor of programmed
cell death. Nature 381, 335–341.
25 Suzuki M, Youle RJ & Tjandra N (2000) Structure of
bax. Coregulation of dim...
Tài liệu Báo cáo khoa học: Arginine ethylester prevents thermal inactivation and aggregation of lysozyme pptx
... presence of NaCl suggest that the
molecular mechanism of ArgEE in preventing thermal
inactivation and aggregation is different from that of Arg.
Thermal unfolding profile of proteins in the presence
of ... allow
evaluation of the T
m
.
Charged states of Arg and ArgEE
In order to understand the importance of amphiphilicity,
titration curves of Arg and ArgEE were compar...
Tài liệu Báo cáo khoa học: The undecided serpin The ins and outs of plasminogen activator inhibitor type 2 pdf
... binding proteins, including the stabilizing protein
HuR [86] and the mRNA destabilizing protein tristetr-
aprolin (TTP) [87]. HuR is a member of the Hu family
of mRNA binding proteins and has ... minireview will focus on the cellular and
molecular biology of PAI-2 and highlight some of
the most recent findings on the role and impressive
pattern of regulation of this e...
Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... dublin TLP and zebrafish TLP are found in the flex-
ible portions of strands B and C that protrude towards
the solvent and in the conformation of the long loop
connecting strands D and E [17]. ... identification and distribution of
TLP genes in nature, the structural and functional
characterization of the TLP from various organisms,
and the evolution of TLP and transthy...
Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
... infarct size and less BBB dam-
age in mouse models of ischemic stroke [87,99,100].
The mechanisms of brain damage involve gelatinase-
mediated disruption of the BBB integrity, of edema
and hemorrhagic ... levels of cytokines and chemokines
enhance the expression of adhesion molecules on cerebral endothelial cells,
facilitating the adhesion and transendothelial migration o...
Báo cáo khoa học: Isoquinoline-1,3,4-trione and its derivatives attenuate b-amyloid-induced apoptosis of neuronal cells pdf
... Alzheimer’s amyloid-
beta precursor protein and amyloidogenic A beta pep-
tide formation. Cell 97, 395–406.
9 Ayala-Grosso C, Ng G, Roy S & Robertson GS (2002)
Caspase-cleaved amyloid precursor protein ... in the pathology
of Alzheimer’s disease [7]. b -Amyloid (Ab) is the major
component of senile plaques and is regarded as playing
a causal role in the development and...