Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression pdf
Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression pdf
... that the translated form may have used a CUG start codon with an N-terminal leu- cine amino acid. Our present study indicates that non- AUG translation initiation may be operable more often than ... Journal 2 74 (2007) 1610–1620 ª 2007 The Authors Journal compilation ª 2007 FEBS Unconventional translation initiation of human trypsinogen 4 at a CUG codon...
Ngày tải lên: 07/03/2014, 10:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
... model of the HIV mature capsid lattice and mutational analysis [39] (Fig. 2E,F) are consistent with the above results. CA–CA interactions and stability of the mature HIV-1 capsid Mutations generally ... oligomeri- zation affinity of CA and the stability balance of the HIV capsid may be a result, in part, of the preserva- tion of intersubunit electrostatic repulsions. Conformati...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly ppt
... FIPSE private Foundation (Exp: 36557⁄ 06) and Generalitat Valenci- ana (ACOMP ⁄ 2009⁄ 185). Drs Mauricio G. Mateu and Francisco N. Barrera are thanked for critically reading the manuscript and for ... dimerization-helix of CTD as an inhibitor of CA dimerization Both structural [8] and thermodynamic [23] analyses indicate that most of the dimerization interface in CA (Fig. 1) is contai...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... picolinic acid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzyme stands at a branch point of the tryptophan to NAD pathway, and deter- mines the final fate of the amino acid, i.e. transformation ... Regulation of mouse hepatic a- amino-b-carbo- xymuconate-e-semialdehyde decarboxylase, a key enzyme in the tryptophan–nicotinamide adenine dinu- cleotide pathway, by...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD) K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein pptx
... by site-directed PCR-based mutagenesis [12,30]. Mutagenic antisense oligonucleotides for MCAD 842 GfiC(5¢-GAT AAAACCACACCTGTAGTAGCTG-3¢) and MCAD 116 5A G(5¢-CCTGTAGAAAGACTAATGAGGGATG CC-3¢) (mutagenic substitutions ... enzyme-deficient human tissue. Proc Natl Acad Sci USA 84, 40 68 40 72. 19 Zeng J & Li D (20 04) Expression and purification of His-tagged rat mitochondria medium-ch...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Multiple enzymic activities of human milk lactoferrin ppt
... enzymic activities of human milk lactoferrin Tat’yana G. Kanyshkova 1 , Svetlana E. Babina 2 , Dmitry V. Semenov 1 , Natal’ya Isaeva 3 , Alexander V. Vlassov 1 , Kirill N. Neustroev 4 , Anna A. Kul’minskaya 4 , ... into the circulatory system or treatment of human respiratory mucosal surfaces with DNases and RNases leads to protection against viral and bacterial diseases [46...
Ngày tải lên: 21/02/2014, 00:20
Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... were amplified by PCR using pairs of primers 5¢-CATATGCAACAGACAACCCAAATTCAGCCC-3¢ and 5¢-AGATCTTATCACTCCCTTACTAAGTCGATG-3¢ for the b subunit and 5¢-CATATGAGCGAGAAAACCA TGCGCGTGCAG-3¢ and 5¢-AGATCTTAGCTTCCTTT ACGCAGCTTATGC-3¢ ... DNA polymerase (Stratagene) and pairs of primers 5¢-TCTGAGTGCGGTGGAAGAGATG ATGAAGCG-3¢ and 5¢-AGATCTTATTCAATGGTGT CGGGCTGAACC-3¢ anddigestedwithEcoRV and BglII. Re...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: The capsid protein of human immunodeficiency virus: interactions of HIV-1 capsid with host protein factors ppt
... 1. Domains of human lysyl-tRNA synthetase. (A) Domain arrangement of LysRS. Amino acid positions of the N-terminal (grey), anticodon binding (AC, orange) and aminoacylation domain with characteristic ... two-hybrid system and glutathione S-transferase pull-down assays to test the ability of Gag mutants to bind CyPA and to self-associate. They observed that mutants unable...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Activator-binding domains of the SWI ⁄ SNF chromatin remodeling complex characterized in vitro are required for its recruitment to promoters in vivo pot
... com- pensatory action of some other factor. The SAGA complex, another Gal4-associated co-activator [30 ,47 ,48 ], is a potential candidate for such a factor because partial redundancy between SWI ⁄ SNF and Gcn5, ... nucleosomes. Taken together, these findings suggest that the predominant coactivating role of SWI ⁄ SNF may be at steps downstream of activa- tor binding rather than as...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo khoa học: Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A⁄C pot
... hsMOK2–S4 6A (Fig. 8C, lower), indicat- ing that the effect of orthovanadate treatment can be mediated by phosphorylation at another position. Human MOK2 is a DNA-binding transcriptional repressor and ... phosphatase inhibitor orthovanadate to enhance cellular phosphorylation. HeLa cells co-transfected with expression vector for lamin C–Q294P and hsMOK2–WT were incubated with...
Ngày tải lên: 07/03/2014, 01:20