Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt

... Bcl-2- binding domain which may serve as a point of cross-talk between the autophagic and apoptotic pathways. Recently, a BH3 domain in the Bcl-2- binding domain of Beclin 1 was shown to bind to Bcl-X L [13]. ... of the autophagosomes and cargo by lysosomal proteases [2,3]. The autophagic pathway is crucial for maintaining cell homeostasis and disruption to th...

Ngày tải lên: 07/03/2014, 09:20

... reduced the response to euge- nin, indicating that eugenin is indeed acting through CCK 2 receptors. To further investigate the interaction of eugenin with CCK 2 receptors, we investigated the effect ... and caerulein both contain a tyrosine sulfate residue; the bioactivity is diminished if the tyrosine sulfate group is hydrolysed [40]. Eugenin corresponds to the c...

Ngày tải lên: 19/02/2014, 16:20

... as follows. We initialize the sampler by randomly as- signing each string in the training corpus a random tree generated by the grammar. Then we randomly select a string to resample, and sample a ... under- lining indicates an adapted nonterminal. Phoneme is a nonterminal that expands to each of the 50 dis- tinct phonemes present in the Brent corpus. This grammar defi...

Ngày tải lên: 20/02/2014, 09:20

... thiolates in solution [26]. On the other hand, the mechanism involved in the binding of Table 1. In uence of the reaction time (t) and binding ability of the counter-ions (X) on the nature and structural ... information on the binding of Hg(II) to the corresponding apo-MT form [23]. In a ddition, compar- ison of the two sets of data gives an indication of the...

Ngày tải lên: 16/03/2014, 18:20

... glucocorticoid administration. The hypothesis of a cause–effect relationship is suggested by the time-course analysis of C/EBPa and CYP3A1 mRNA and protein accumulation in the liver. Our in vitro and the in vivo results indicate ... these regulatory elements in the response to glucocorticoids, the concurrence of the CYP3A1 and the C/EBP responsiveness w...

Ngày tải lên: 17/03/2014, 09:20

... RA, and this is accompanied by an increase in apoptosis [73]. The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2. The ... expres- sion in the face and limbs. In a follow-up study, they found that this conserved cis-acting sequence serves to maintain a level of AP-2a expression that limits...

Ngày tải lên: 16/02/2014, 09:20

... far, little is known about amino acid catabolism in insects. It is hoped that the sku mutant will give insights into the unique catabolism of branched-chain amino acids in insects. Using recently ... mechanism bypassing branched-chain a-keto acid dehydrogenase irreversibility, which enables indirect accumulation of upstream leucine in the sku mutant. It is interesting that i...

Ngày tải lên: 18/02/2014, 04:20

... systemic in am- matory disease that occurs in about 1% of the popula- tion. The in ammatory process is characterized by in ltration of in ammatory cells into the joints, leading to the proliferation ... polyarticular joint dis- ease that primarily affects the small joints of the hands and feet. The in ammatory process is characterized by in ltration of in am...

Ngày tải lên: 18/02/2014, 18:20

... of these materials (e.g. N e -carboxymethyl-lysines and N e -carboxy- ethyl-lysines and pentosidine) being known to accumu- late with age on tissue proteins, and at an increased rate in LDL and ... scavenger receptors SR-A and CD36. The accumulation of lipid in these macrophages is accompanied by increased endocytosis and degradation of apoB, with the difference in...

Ngày tải lên: 19/02/2014, 02:20

... the amino acids interacting with the substrate (black, according to [44]). The heme is presented in green to localize the active site. The I and J helices are labeled; the a helices are red and ... of CYP6A1 and CYP6D1 has been documented in the house fly, but there is no link between these instances of polymorphism and insecticide resistance [7,13,14]. These...

Ngày tải lên: 19/02/2014, 12:20