Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc

... missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa Yoshihiro Yamanishi 1 , Hisaaki Mihara 2 , Motoharu Osaki 2 , Hisashi ... eukaryotes and archaea, and there is also variation within bacteria. We also focused on the lysine-degradation pathway because the substrates and intermed...

Ngày tải lên: 07/03/2014, 09:20

... hypotheses that are consistent with the data and achieve this in a value-free manner. Much of classical biochemis- try and signalling pathway analysis has concentrated on the analyses of changes in the ... visualiz- ing, and integrating molecular pathway data. J Biomed Inform 37, 43–53. 306 Hoffmann R, Krallinger M, Andres E, Tamames J, Blaschke C & Valencia A (2005)...

Ngày tải lên: 07/03/2014, 12:20

... Since ad-hoc manual translation can represent a significant investment in time and money, a prior assesment of the amount of training data required to achieve a satisfac- tory accuracy level can ... Linguistics Prediction of Learning Curves in Machine Translation Prasanth Kolachina ∗ Nicola Cancedda † Marc Dymetman † Sriram Venkatapathy † ∗ LTRC, IIIT-Hyderabad, Hyderabad,...

Ngày tải lên: 07/03/2014, 18:20

... referenced argument of a j , 5) a i ACa j : a j is the continuation argument of a i , 6) a i CAa j : a i is the continuation argument of a j , 7) a i = a j : a i and a j are labeled as the same role label, ... automatic parsing data. 2 Prediction of Thematic Rank 2.1 Ranking Arguments in PropBank There are two main problems in modeling the- matic hi...

Ngày tải lên: 17/03/2014, 02:20

... groups and testing against the remaining group and a false data set. The false data sets were created by dividing the remaining sequences in the ASTRAL data set (4701 sequences) into six equally ... mem- brane-attached. The transmembrane (TM) helix can be found in either the N-terminal part of the protein, as in 11-beta hydroxysteroid dehydrogenase type 1 [11], or in...

Ngày tải lên: 23/03/2014, 10:21

... catalyzed by ACC – the key reg- ulatory enzyme in the pathway. Malonyl-CoA serves as the basic chain-elongating substrate for the formation of long-chain saturated fatty acids catalyzed by FAS. It ... in various organ systems. Even in organisms lacking a brain, such as Caenorhabditis elegans, the nervous system plays a key role in maintaining energy balance [1–4]....

Ngày tải lên: 14/02/2014, 22:20

... 5¢-GCC GTA GCC AAC CTC GCA GCC GAA TAC GCC TAT TAT-3¢ and 5¢- ATA ATA GGC GTA TTC GGC TGC GAG GTT GGC TAC GGC-3¢; for the C27 6A ⁄ C28 2A mutant, 5¢-GGC GTA GCT ACA ATG GCG AAG CAT GCC GGA CAT-3¢ and ... of radical-AdoMet enzymes. Abbreviations AdoMet, S-adenosyl- L-methionine; anSME, anaerobic sulfatase-maturating enzyme; anSMEbt, Bacteroides thetaiotaomicron anaerobic sulfatase-matur...

Ngày tải lên: 16/02/2014, 14:20

... an unexpected decrease in PMP-BSA binding. It thus appears that tethering of the C-terminal end of the ectodomain is important for both IGF-II and PMP- BSA binding. In summary, the major findings ... shown as rectangles. The shaded rectangles indicate repeats 3 and 9, to which the main determinants of Man-6-P binding have been mapped. The stippled rectangles represent rep...

Ngày tải lên: 18/02/2014, 08:20

... riboflavin biosynthetic pathway in plants is similar to that of eubacteria, rather than that in fungi and archaea. In view of the close similarity between puta- tive plant deaminases and their apparently ... putative plant pyrimidine reductase domains catalyse the equivalent reduction to RibD proteins. In these proteins, the associated deaminase domains lack an invariant zi...

Ngày tải lên: 18/02/2014, 18:20

... fragment was treated with cisplatin in the same way, the inten- sity of the R 53 band on the autoradiogram increased with the degree of DNA modification. The increase was already significant at ... double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Nature 377, 649–652. 29 Zlatanova J, Yaneva J & Leuba SH (1998) Proteins that specifically...

Ngày tải lên: 19/02/2014, 05:20