Báo cáo khoa học: Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma pot

... 2008 FEBS 3247 Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma Subrata Patra 1 , Soumen Bera 1 , Soumya SinhaRoy 1, *, Sarani ... unable to retain their intra- cellular creatine pool in the form of phosphocreatine. The simultaneous decrease in phosphocreatine, crea- tine and C...

Ngày tải lên: 07/03/2014, 06:20

... predominant transcript in the adult intestine and in the developing embryo, whereas Mxi1-SRb transcripts predominate in the adult liver and kidney [12]. In our initial description of Mxi1-SRa and ... many of the biological properties attributed originally to Mxi1 and outlined above (we have renamed the original Mxi1 isoform Mxi1-SRb) [12]. Specifically, Mxi1-SRa can also...

Ngày tải lên: 18/02/2014, 16:20

... media To examine changes in iron metabolism parameters we examined expression of the transferrin receptor, ferritin and storage iron in HepG2 cells grown in media sup- plemented with 100 lm of ferric ... Quantification of DNA content by flow cytometry revealed that the inhibition of cell growth was due to a decrease in the percentage of cells in the S and G2 ⁄ M ph...

Ngày tải lên: 19/02/2014, 16:20

... to restore monomers and inhibi- tory activity under nondenaturing conditions. Loss of inhibitory potential of dimerized cystatin F can be explained by blocking of the N-terminal part, disabling protease ... process regulating its inhibitory properties. Screening of proteases for their inhibition showed that cystatin F is different from other cystatins, both in terms of specific...

Ngày tải lên: 19/02/2014, 17:20

... apoptosis, insulin receptor substrate 1, mammalian target of rapamycin kinase (mTOR), mitogen-activated protein kinase kinase 3, c-Jun N-terminal kinase, translation elongation factor eEF2 and ... phosphatidylinositol 3 -kinase inhibitor wortmannin, no other details of this insulin process are known. A novel and physiologically interesting observation of the present study was...

Ngày tải lên: 07/03/2014, 15:20

... families of protein tyrosine phosphatases [1]. In eukaryotic cells, lmwPTPs participate in platelet-derived growth factor (PDGF)- induced mitogenesis [2] and insulin-mediated mitotic signaling [3]. ... missing in prokaryotic lmwPTP, whereas the role of its indole side-chain in the stabilization of the dimer seems to be taken on by the phenyl group of F40 of YwlE. Residue...

Ngày tải lên: 16/03/2014, 02:20

... phosphatidylinositol; PtdIns3K, phosphatidylinositol 3 -kinase; PKB, protein kinase B ⁄ akt; PKC, protein kinase C. 4372 FEBS Journal 272 (2005) 4372–4384 ª 2005 FEBS lead to activation of downstream kinases including protein ... Woodgett J & Dedhar S (1998) Phosphoinositide-3-OH kinase- dependent regulation of glycogen synthase kinase 3 and protein kinase B ⁄ AKT by th...

Ngày tải lên: 30/03/2014, 20:20

... 4625 response to glucose, suggesting the importance of PKA in protein trafficking [47,48]. In this study, we used PKA knockout mutants to determine the role of PKA in mitochondrial targeting of CYP2E1. In ... shown). Role of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The...

Ngày tải lên: 18/02/2014, 16:20

... counterstaining. Haematoxylin–eosin staining Haematoxylin–eosin staining was carried out following the routine histological method described by Kayser and Bubenzer [38]. The haematoxylin–eosin staining technique employs ... was to delineate the regulatory mechanisms of folate transport in intestinal absorptive epithelia in order to obtain insights into folate malabsorption in a...

Ngày tải lên: 18/02/2014, 16:20

... determine the calcium-binding domain of the protein. (A) Schematic drawing of the recombinant proteins. Six GST-fused recombinant proteins containing the three distinctive domains of tandem repeat 1 ... to the beads. By contrast, incubation with otolith extract resulted in binding of a complex of the HMW aggregate containing OMM-64 and otolin-1 to the beads. H. Tohse et al....

Ngày tải lên: 18/02/2014, 17:20