Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc

... the involvement of lysine- containing sequences in the acti- vation mechanism. Involvement of lysine residues contained within a 1 CB6 peptides In order to localize lysine residues in sequences involved ... derived from jararhagin disin- tegrin) is essential for binding to the I domain of a 2 integrins [24]. Similarly, members of the lysine threo- nine–serine (KTS)–di...

Ngày tải lên: 07/03/2014, 06:20

... spicule (Fig. 2H). These silica vesicles often remain as intact entities within the rings ⁄ cylin- ders, reacting positively to anti-silicatein (Fig. 2H). Catalytic function of silicatein: silica ... polymerase activity of silicatein, involves stepwise addition of single silica monomeric units. This finding implies that silicatein has two different enzymatic properties, a silica esterase...

Ngày tải lên: 18/02/2014, 16:20

... carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate is ... identified in plots of k lim ⁄ K d of pK a values 7.1 and 9.3, again with the maximum value realized in the alkaline region. The poten- tial origin of these kinetically in uential ionizat...

Ngày tải lên: 19/02/2014, 07:20

... Characterization of hydride transfer to flavin adenine dinucleotide in neuro- nal nitric oxide synthase reductase domain: geometric relationship between the nicotinamide and isoalloxazine rings. ... compilation ª 2008 FEBS errors in the estimation of the midpoint potentials. However, it is more likely that there is thermodynamic mixing of the species during potentiometric titration,...

Ngày tải lên: 07/03/2014, 06:20

... and this will affect the strength of coenzyme B binding. A more important function of the methyl group may involved improved orientation of the histidine inside the coenzyme B-binding site. With ... and MoaD, involved in thiamine biosynthesis and molyb- dopterin biosynthesis, respectively, and for the sulfura- tion of uridine in tRNA to thiouridine can be envisaged [34–36]. This m...

Ngày tải lên: 16/03/2014, 05:20

... resi- dues in close proximity to the bound substrate in TOP, including Tyr612 and residues contained in the loop region 599–611 that join domain I and II. Supported by computational studies, activity ... both impli- cated in substrate binding, are shown in Fig. 3 to be within hydrogen bonding distance from the substrate. As energy minimization only allows for limited con- formatio...

Ngày tải lên: 23/03/2014, 06:20

... in macrophages by stimulating incorpor- ation of acyl-CoA into TG as well as by inhibition of fatty acid oxidation. This contrasts with findings in ADRP-deficient mice, in which no difference in ... loading with VLDL. In contrast, inhibition of adipo- philin expression using siRNA prevented lipid-droplet formation and signi- ficantly reduced intracellular triglyceride content. Us...

Ngày tải lên: 23/03/2014, 10:21

... compilation ª 2007 FEBS Oxidative deamination of a lysine residue The oxidative deamination of a lysine residue was monitored through the formation of a-aminoadipic-d- semialdehyde-derivatized ... DABY inhibition mechanism; that is, the reactive turnover product of DABY binds an amino acid residue without interfering with the TPQ function. Discussion In the past decade, several...

Ngày tải lên: 30/03/2014, 09:20

... structural organization that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and ... AT-hook is a DNA-binding domain. Bromodomains (BROMO) are involved in the recognition of acetylated lysine residues in histone tails. CXXC-zf is a Zn-finger domain involved in pro...

Ngày tải lên: 16/02/2014, 14:20

... presence of thapsigargin. However, in contrast to a report on pancreatic acinar cells, where PI3-K inhibition increased Ca 2+ mobilization via SERCA activation [30], PI-3K inhibition did not alter ... antagonized this effect (Fig. 4A). In marked contrast, preincubation with the PI3-K inhibitor wortmannin was ineffective. Further experiments confirmed the sensitivity of InsP 3 -induce...

Ngày tải lên: 18/02/2014, 16:20