Báo cáo khoa học: Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines doc

... characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine–Fe(III) complex. Reversal of the endoge- nous feedback inhibition by phosphorylation of serine- 40. ... mechanisms of TH feedback inhibition FEBS Journal 275 (2008) 2109–2121 ª 2008 The Authors Journal compilation ª 2008 FEBS 2121 Endogenous tetrahydroisoquinol...

Ngày tải lên: 07/03/2014, 05:20

... lead to these diseases and will be a major step forward in our understanding of the pathogenesis of PD and ultimately to the development of novel therapeutic approaches. Acknowledgements The authors ... mutations causing familial forms of Parkinson’s disease have provided insight into the molecular mechanisms that underlie the genetic and sporadic forms of this diseas...

Ngày tải lên: 18/02/2014, 14:20

... together data suggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism. One shortfall of the present theory ... metabolism. Levels of cellular ceramide are regulated by the de novo pathway and the recycling pathway. The former relates to the synthesis of ceramide through the...

Ngày tải lên: 18/02/2014, 14:20

... effect of these mutations on the electron transfer process. To elucidate the mechanism by which mutations on the J helix and in the vicinity of the b sheet 3–3 can affect the catalytic properties of ... had no effect on the spectra. The type of substrate- induced binding spectra was determined by the positions of the peak and the valley on the spectrum [4...

Ngày tải lên: 19/02/2014, 12:20

... and the ability of the particular p53 target site to accommodate the cisplatin IACs. The higher the probability of formation of the cisplatin IACs within the p53DBSs due to the occurrence of the ... treated with the drug in excess of nonspecific calf thymus DNA. Inter- action of the protein with any of these targets was sig- nificantly affected by the...

Ngày tải lên: 19/02/2014, 05:20

... best-scoring hypothesis z i is found, and if it differs from the refer- ence y i , then the cost of each feature 2 is increased by the count of that feature in z i and decreased by the count of that feature ... that the construction of the language model requires two choices. The first concerns the choice of the set of n-gram features Φ i for i = 1 . . . d imp...

Ngày tải lên: 23/03/2014, 19:20

... is the frequency of noun nj occurring as the argument of adjective ai, fadj(nj) is the frequency of the noun nj oc- curring as the argument of any adjective, f(ai) is the frequency of the ... frequency of noun nj occurring as the subject of verb vi, L~,b(n~) is the frequency of the noun nj occurring as subject of any verb, f(vi) is the fre...

Ngày tải lên: 31/03/2014, 21:20

... pLGD 17 -265UP1wasusedasthebaitwithan insertion of three copies of the O2S domain at the 5¢ end of the CYC1 mini-promoter region. Following transfor- mation of the URA-marked plasmid pLGD-265 UP1 containing the ... specifically to the O2S elemen t. We have also determined the importance of the amino acids within the binding domain of RAMY protein and analyzed the...

Ngày tải lên: 16/03/2014, 18:20

... if so, whether this involved: (a) augmentation of the unfolded protein response (UPR); (b) up-regulation of members of the inhibitor of apoptosis protein (IAP) family; and ⁄ or (c) inhibition of JNK ... and the ability of PI3 kinase ⁄ Akt to suppress the c-Jun NH 2 terminal kinase (JNK) pathway has been studied in a variety of cell types [20]. Therefore, excess lipid d...

Ngày tải lên: 29/03/2014, 23:20

... and binds to PIP 2 The molecular modelling of the last 300 amino acid residues of Krit1 that we generated corroborates the existence of a FERM domain at the C-terminus of the protein. FERM domains ... cleft on the Krit1 FERM model that we generated. Mutagenesis analyses of these residues will help to determine whether the binding site of the polar head of PIP 2 o...

Ngày tải lên: 16/03/2014, 05:20