Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
... FEBS Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature Francesca ... transition state in cold thermal regimes. How do the unique features of the E. focardii c-tubu- lins enhance microtu...
Ngày tải lên: 07/03/2014, 04:20
Tài liệu Báo cáo khoa học: Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites doc
... Ile8 of the peptide interacting with the Tyr752 hydroxyl group of the enzyme. A hydrophobic interactionofthesidechainofMet1ofTat(1–9)withthe phenyl ring of the substrate Ala-Pro-pNA resulted in ... considerable stabilization of the complex. The interactions of the C-terminus as well as the N-terminus of Tat(1–9)-related peptides permitted the dock- ing of th...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... switching induces conformational changes in the FG loop region and movement of t wo subunits. These structural changes may play critical roles in c atalytic regulation of the PD E domain [4]. Structures ... potential of the haem, rate constants o f CO, O 2 and CN b inding to haem, and CD spectra in the Soret region [15–18], suggesting that this residue is critical for...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: "Word Vectors and Two Kinds of Similarity" pptx
... spaces. Another interesting finding is that there was no clear peak in the graphs of Figure1. For SPI test items, correct rates of the three methods increased linearly as the number of dimensions increased, r ... df j denotes the number of words whose sense definitions contain the word t j . The second term in parentheses in Equation (4) means the square root of t...
Ngày tải lên: 20/02/2014, 12:20
Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... reinforce the argument that the basic domain should be exposed at the surface of the Tat-containing recombinant proteins and call other reasons to explain the differences in the mechanism of internaliza- tion ... s under evaluation. Comparative FACS analysis of the internalization of the full-length Tat protein construct and the Tat CPP Differences in the mec...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... counterparts, in agreement with the higher mass of BChE subunits [37]. This indicates a predominant in uence of the catalytic domain on oligomerization. Role of the C-terminal cysteine Mutation of the ... modified, suggesting that degradation was increased by suppres- sion of the cysteine. Thus, it appears that the effect of a C-terminal cysteine on the trafficking...
Ngày tải lên: 07/03/2014, 03:20
Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... was recently examined for mutations, and clus- tering of mutations was detected in the part of the gene encoding the ATP-binding pocket. Screening for such mutations may identify patients who will ... activation of caspase 3 in human non- small cell lung cancer cell line PC-9. To investigate the signaling route by which AG1478 induced apoptosis, we examined the activatio...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... analysis, and the determination of released ammonia. The coupled enzyme assay revealed the mechanism of the deamination reaction and the subsequent metabolism, including the deamination step. The product ... prepared by incubating catechol with resting cells of a mutant, strain Y-2, of the aniline-assimilating Pseudomonas sp. strain AW-2 [20]. Results Spectral changes...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx
... euge- nin, indicating that eugenin is indeed acting through CCK 2 receptors. To further investigate the interaction of eugenin with CCK 2 receptors, we investigated the effect of eugenin on lymphocyte ... is due to the release of acetylcholine from cholinergic nerve terminals, the effects of eugenin and CCK-8 were determined in the presence of atropine (10 )6 m). This...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx
... the parses assigned to the training data at the end of sampling, and for the last two epochs we annealed at temperature 0.5 (i.e., squared the probability) during sampling in or- 400 1 10 100 1000 U ... sample a parse of that string with a PCFG approximation to the adaptor grammar. This PCFG contains a production for each adapted subtree in the parses of the...
Ngày tải lên: 20/02/2014, 09:20