Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

... the PI3K/Akt signaling pathway leads to inhibition of PrP C -induced cell drug resistance in gastric cancer cells. PI3K/Akt is involved in the activation of P-gp by PrP C in gastric cancer To ... significantly increased. The results indicate that inhibition of the PI3K/Akt signaling pathway may lead to inhibition of the MDR induced by Pr...

Ngày tải lên: 07/03/2014, 03:20

... lysine or arginine residue. Hence, peptide fragments not featuring a lysine or arginine residue in the C-terminal ends or truncated in the N-termini by some amino acids rela- tive to the preceding ... unique to media of cells expressing activated meprina ⁄ b and 40 to media of cells with non-activated meprina ⁄ b (Table 1). These unique protein spots were therefore abs...

Ngày tải lên: 07/03/2014, 06:20

... binding for M 2+ (M ¼ Zn, Cd) initially to the a domain, thereby lead- ing to formation of the M 4 a cluster prior to formation of the M 3 b cluster, demonstrating that the individual binding ... the meta- llation mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation of the metallation details of the two-domain...

Ngày tải lên: 19/02/2014, 00:20

... bridge to the increase in the Gibbs free energy of activation of unfolding under native conditions. Using the linear extrapolation model [27], the rate constant for the unfolding of G8C ⁄ N60C in the ... the intermediate in the unfolding. Calcium ions are the main contributory factor to enzyme stability The binding of calcium ions seems to be the main...

Ngày tải lên: 19/02/2014, 17:20

... production of these morphemes in an attempt to determine in which way these morphemes are related to the words. Are they unified with the word in all instances or only in certain contexts? Adapting ... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The...

Ngày tải lên: 21/02/2014, 20:20

... help them during the design phase, being able to reuse workflows (or parts of them) and thus avoiding reinveinting the wheel. 4 Using the tools to work with NLP All the aforementioned tools were installed, ... needs to be adapted to the TO, this way we can interconnect the different tools in the platform regardless of their original input/output formats. We have ad...

Ngày tải lên: 22/02/2014, 03:20

... conformation, the SH2 domain binds to pY i on the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linker between the SH2 and kinase domains at the back of the small lobe, preventing the ... human umbilical vein endothelial cells were mechanically stimu- lated by applying the laser-tweezer traction to fibronec- tin-coated beads adhering to the...

Ngày tải lên: 18/02/2014, 11:20

... : 2000 in blocking solution for 30 min. Cells were rinsed in NaCl ⁄ P i several times and incubated in blocking serum containing anti-mouse IgG (Vectastain) for a fur- ther 30 min. Staining was ... 2). These data indicate that both peptides accumulate in inclusion bodies, and that Ab(L1–40) is the dominant protein in the inclusion bodies. In contrast, the major protein in...

Ngày tải lên: 18/02/2014, 13:20

... test. Starting with each complex in the training set containing one or more RRM or KH domains, we extracted the protein coordinates and the four nucleotides bound at the center of the domain (for structures ... amino group of C5 and the O1P atom of U6 observed in the structure of the MS2–RNA complex containing a cytosine at position )5 that helps organize the RNA...

Ngày tải lên: 18/02/2014, 16:20

... substrate. The binding site of the NS2B cofac- tor could be examined for a view to inhibitor develop- ment, and competitive inhibitors of the binding site might be able to inhibit the correct fold of the ... the buried carboxyl via the histidine to the serine. The transfer of the Ser Oc proton to the histidine converts the serine into a strong nucleophi...

Ngày tải lên: 19/02/2014, 00:20