Báo cáo khoa học: High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease pdf

... low- molecular-weight heparin and N-acetyl heparin promote an increase in FSAP activity rather than inhibiting it. Thus, polyanion binding to SERPINs, over and above their binding to FSAP, plays a decisive role in ... potential for binding to and activating FSAP. The heparin homologues N-acetyl heparin, de-N-sul- fated heparin and N-acetyl-de-O-sulfated heparin, which h...

Ngày tải lên: 07/03/2014, 02:20

... chmu ¨ lling, T. (2003) Cytokinin-induced upregulation of cytokinin oxidase activity in tob acco includes changes in enzyme glycosylation and secretion. Physiol. Plant. 11 7, 11–21. 41. Tingay, ... seedlings. The measured v alues are summarized in Table 2. The total cytokinin content in the grains was approximately threefold lower than in young seedlings. The increase was mainly o...

Ngày tải lên: 19/02/2014, 16:20

... obtained to date indicate that inhibition of Ras activity suppresses cell proliferation and induces regression in a broad range of tumors. Intracellular antibodies, in particular single-chain ... c), anti-(Ras 1) (d, e and f) and anti-Ras 6 scFv (g, h and i) fragments. Cells were first costained in vivo with annexin V (b, e and h) and Hoechst 33342 dye (c, f and i) and, su...

Ngày tải lên: 21/02/2014, 00:20

... co-occurrences. A greedy Viterbi training is then applied to improve this initial guess. In contrast, our BP/EM training do not need to compute correlation scores and start the training with uniform parameters. We ... (Chauch ´ e, 1984) and for Japanese, the KNP parser (Kuro- hashi and Nagao, 1994). The line SDM:Parsing (SDM standing for “Structure-based Distortion Monolink”) shows th...

Ngày tải lên: 22/02/2014, 02:20

... (1986) Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competi- tive binding studies. Anal Biochem ... demon- stration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by...

Ngày tải lên: 18/02/2014, 08:20

... procedures. Final protein concentration was in all cases 45 l M and final concentration of Cu 2+ 46 lM, leading to 1 : 1 of protein to Cu 2+ ratio. Results for 1 : 3 pro- tein to Cu 2+ ratio have ... places, but in particular, stefin B has a number of histidines in the C-terminus (box in Fig. 1) at sites: 92, 75, 66 and 58. As histidine residues are central to copper binding in...

Ngày tải lên: 19/02/2014, 06:20

... Tyr304 in the cytoplasmic tail of ephrin B2 confers high- affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein Zhengding Su, Ping Xu and Feng ... CPHYEKVSGDYGHPVYIVQEMP(301–322) for ephrin B2, which was shown to be responsible for Grb4 binding and is identical in both ephrin B2 and ephrin B1 [11]. Strikingly, the Grb4 SH2 do...

Ngày tải lên: 19/02/2014, 12:20

... serine proton is the catalytic histidine. Most models use the histidine to shuttle protons: first, between the serine and the leaving group; and then between the attacking water and the serine. In ... on pH involving a single pK a [29]: pH ¼ pK a À log k À k A k H À k  The term k stands for the observed rate, k A stands for the limiting rate at high pH, and k H stands for the lim...

Ngày tải lên: 20/02/2014, 23:20

... Germany In bacteria, archaea and plants, the biosynthesis of l-cysteine involves l-serine and inorganic sulfur com- pounds [1–5]. In higher animals, however, l-cysteine is derived from l-methionine ... lies in the usual range and does not change for T68S and R210A. In contrast, mutants Q140A and T68A showed much higher temperature dependence factors, corresponding to an appr...

Ngày tải lên: 07/03/2014, 05:20

... assessment-insulin resistance were inde- pendent determinants of mean IMT level. Conclusion: Obesity especially abdominal obesity, high TG and insulin resistance may be the main risk predictors of increased ... lg (HOMA-IR) and TG in both bivariate correlation and multiple stepwise linear re- gression analysis, suggesting a link between IMT, insulin resistance and dyslipidemia...

Ngày tải lên: 25/10/2012, 11:40