Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt

... samples in vivo and in vitro. We also describe the use of NMR spectroscopy to determine the binding mode of new low molecular mass inhibitors of the West Nile virus NS2B–NS3 protease which were discovered ... The Authors Journal compilation ª 2009 FEBS 4255 NMR study of complexes between low molecular mass inhibitors and the West Ni...

Ngày tải lên: 07/03/2014, 02:20

... polysaccharides degraded and of the sugars solubilized should aid in the understand- ing of the action of the cellulolytic system and in the evaluation of its efficiency in the degradation process. We ... those observed at the given times. The concentrations of the metabolites were calculated from the quantification of the signals in the 1 H NMR spectra...

Ngày tải lên: 23/03/2014, 07:20

... features produces the best results. A subsequent innovation was the detection and removal of the objective parts of documents and the application of a polarity classifier on the rest (Pang and Lee, 2004). ... max t (tf) is the maximum frequency of any term in the document and avg dl is the average number of terms in all the documents. For ease of reference...

Ngày tải lên: 20/02/2014, 04:20

... average co-ordinates (the blue colour denotes the side chains of Arg2, Tyr4, Ile5, His6 and the yellow the side chains of Val3 and Pro7) (a) with the the X-ray structure of AII in the Fab131–AII complex ... 2003 On the molecular basis of the recognition of angiotensin II (AII) NMR structure of AII in solution compared with the X-ray structure of AII boun...

Ngày tải lên: 20/02/2014, 23:20

... polymorphism of monomeric subunit c is due to the interaction of the monomer with the artificial environment lacking the stabilizing protein/protein contacts within the ring. The undecameric c ring of the ... table, and resist boiling in SDS for 5 min in the case of the undecameric c ring of P. modestum [41]. This stability of the ring makes structural flexibil...

Ngày tải lên: 08/03/2014, 10:20

... sentences. In another study, Whittemore, Ferrara, and Brunner (1989) quantify the occurrence of PPs in the 13 dialogues in terms of the syntactic types to which they attach and the overall syntactic ... b. the size of the hotel The algorithm for the other group is: Check to see if preceding lowest consti- tuent is a definite NP and part of a partitive ex...

Ngày tải lên: 08/03/2014, 18:20

... study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer Scott A. Waldman 1 and Andre Terzic 2 1 Departments of Pharmacology and Experimental Therapeutics and ... leukemia cells [31]. Indeed, there is a reciprocal relationship between the expres- sion of miR-15a and miR-16-1 and of Bcl-2, and the heterologous production of t...

Ngày tải lên: 16/03/2014, 01:20

... and cloned between the cytomegalovirus (CMV) promoter and the start codon of the Gaussia luciferase gene of the optical reporter gene vector (Fig. 1C). The Bioimaging of miRNA biogenesis and regulation ... pre-miRNA by Dicer. The synthetic duplex form of pre- miRNAs carrying quencher and organic dye at each strand can be designed. In the presence of the Dic...

Ngày tải lên: 16/03/2014, 01:20

... esti- mation of the bandwidth and the intensity of the bands making up the amide I or I¢ region. Thereafter, curve fitting was performed and the heights, widths and positions of each band were optimized ... this study we used IR spectroscopy to study the secondary structure of the catalytic domain of PKCf and the effect of its substrate, MgATP, and als...

Ngày tải lên: 16/03/2014, 13:20

... together, these results suggest that the DNA-binding step corres- ponding to phase I accounts for the formation of non- specific complexes and that, at the beginning of phase II, the majority of complexes ... product. The stability of IN during the time-course of the reaction and the influence of protein aggregation are discussed. Results General features of...

Ngày tải lên: 16/03/2014, 13:20