Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx

... biology, regulation and inhibition of b-secretase (BACE-1) Clare E. Hunt and Anthony J. Turner Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, ... Specificity of memapsin 1 and its implications on the design of memapsin 2 (b-secretase) inhibitor selectivity. Biochemistry 41, 8742–8746. Biology and chemis...

Ngày tải lên: 07/03/2014, 00:20

... 85% inhibition of BHLmL2 and BHAb, respectively, while 1 mm 2-mer- captoethanol caused 85% and 97% inhibition of BHLmL2 and BHAb, respectively. The influence of pH on the activities of the BH enzymes ... 6 and Fig. 4, the Hill equation provided an excellent fit, with coefficients of determination of 0.992 for BHLmL2 and 0.997 for BHAb. In addition, the fits of the V =...

Ngày tải lên: 18/02/2014, 14:20

... reported in terms of the F-measure, which is the harmonic mean of precision and recall. The first column in both tables indicates the possi- ble names or newgroups, and the number of contexts associated ... the percentage of the majority class (MAJ.) and count (N) of the total number of contexts for the names or newsgroups. The majority percentage provides a simple baseline f...

Ngày tải lên: 08/03/2014, 04:22

... overexpression approach of RpCAbr and RpCAtr, we cannot know the functional effect of changes of some key amino-acids. Origin and number of nonvertebrate CAs Although the bootstrap values of the deep branches ... 0.5 lL of BSA (10 mgÆmL )1 ), 1 lL of total RNA (1.24 lgÆlL )1 ), 2.5 lL of dNTP (4 mm total), 1.5 lL of Random Primer 9 (Ozyme, St-Quentin- en-Yvelines, France...

Ngày tải lên: 18/02/2014, 16:20

... (A) Expanded view of peaks at m ⁄ z 2800.36 and 2832.35 and the fragmentation of the peak at m ⁄ z 2800.36. (B) Expanded view of peaks at m ⁄ z 2934.36 and 2950.35 and the fragmentation of the ... C53S 2-Cys Prx. Expanded view of peaks at m ⁄ z 2800.36 and 2832.35 and the fragmentation of the peak at m ⁄ z 2832.35. 2-Cys Prx was digested with trypsin and prepared for...

Ngày tải lên: 18/02/2014, 17:20

... G250, and the four bands corresponding to subunits of porcine complex II were cut out and N-terminal sequenced by the Edman degradation method and amino acid analyzer in the Department of Biology, ... preparation of complex II. The four subunits of complex II are labeled on the left, and the positions of molecular weight standards are indicated on lane 2. X. Huo et al. Cha...

Ngày tải lên: 19/02/2014, 02:20

... Odom 2 and David L. Herrin 2 1 Department of Biochemistry, Tapei Medical University, Taiwan 2 Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, ... majority of product comes from the highly active fraction. Hence, plots of the percentage of total RNA that is InDG b yield n and m from Eqns 5 and 6. T C. Kuo et al. Mn...

Ngày tải lên: 19/02/2014, 07:20

... spectrometry and the lability of the sulfogroup in mass spectrometry analysis allows recognition of the modification, and differentiation of sulfotyrosine and phosphotyrosine [38]. Characterization of the ... verification of tyrosine sulfation in a-PnIA and a-PnIB and revision of those sequences were made in an investigation of labile sulfo- and phospho- peptides by el...

Ngày tải lên: 19/02/2014, 12:20

... comparison of D U , D T , log 10 f with ∆ log 10 f quency (log 10 f). D U = U w ˜ U w is defined as the ratio of the actual number of users of word w (U w ) over the expected number of users of w ( ˜ U w ), ... in one of the German and English CELEX wordlists are automatically classified as such. This improved classifier results over tokens and types, as seen in Table 1 in the...

Ngày tải lên: 19/02/2014, 19:20

Ngày tải lên: 20/02/2014, 18:20