Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt

... (2009) 1962–1974 ª 2009 The Authors Journal compilation ª 2009 FEBS Differential recognition of heat shock elements by members of the heat shock transcription factor family Noritaka Yamamoto 1 , ... Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15, 1118–1131. 2 Voellmy R (2004) On me...

Ngày tải lên: 07/03/2014, 00:20

... form of the molybdenum cofactor. The ability of various metals to bind tightly to sulfur-rich sites raised the question of whether other metal ions could be inserted in place of molybdenum at the ... requiring the catalytic activity of the MoeA protein. Although the synthesis of the dioxo Moco found in hSO seems to be more susceptible to nonspecific metal insertion,...

Ngày tải lên: 23/03/2014, 06:20

... A proportion of caspase-2 D1)149 was cleaved to remove the small subunit, thereby permitting detec- tion of the dissociated large subunit. The activities of these different forms of caspase-2 were ... caspase-3 and caspase-7), which then catalyse the cleavage of numerous cellular substrates [4]. Despite being the second identified member of the caspase family, the fu...

Ngày tải lên: 23/03/2014, 13:20

... [2]. One of these is the subfamily comprising Axl, Sky and Mer (as we shall refer to them hereafter), also referred to as the TAM family (Tyro3, Axl and Mer). This RTK subfamily is defined by a combination ... and Mer. Furthermore, a hallmark of the Gas6–Axl system is the unique ability of Gas6 and pro- tein S to tether their non receptor-binding regions to the negatively c...

Ngày tải lên: 19/02/2014, 05:20

... deoxyGb 3 binding Based on these results, we suspected that modification of the VT1B by FITC-conjugation might have subtly altered the ability of VT1B to bind Gb 3 . We therefore compared the binding of FITC-labelled ... gate at 800 Da. The mass spectra were externally calibrated with the molecular mass of a mixture of standard peptides. Results Comparison of ligand/Gb...

Ngày tải lên: 16/03/2014, 16:20

... (Fig. 4B). The finding of these differential functions is in line with the dogma that the proteome gains functional complexity by encoding multiple isoforms of a given protein, with these isoforms ... alternative isoforms of members of the p53 ⁄ p63 ⁄ p73 [23] and the Bcl2 families [24]. On the molecular level, we show that the unique PRD on Mxi1-SRa contributes to...

Ngày tải lên: 18/02/2014, 16:20

... the face of temperature acclimation. Therefore, we think that the described mechanism maintains either (a) the kinetic⁄ thermody- namic properties of this metabolic node by ‘dilution’ of the major ... in the sub- unit contact area of the tetramer, whereas the remaining two mismatches sur- round the contact area; this is expected to manifest in the kinetic and therm...

Ngày tải lên: 19/02/2014, 02:20

... that the majority of Ret partitioned in the DRM fraction. This was in contrast to the 2a Ret Y1062F mutant, where the majority of Ret was found in the SUP fraction (Fig. 1A). To test whether ... performed by placing electrodes along the rostral–caudal axis of the neural tube. The egg was then closed and placed in an incubator until the embryos had grown to stage 24 (...

Ngày tải lên: 07/03/2014, 05:20

... result of the residue’s location at the edge of the dimer–dimer interface. The maximum oligomer size obtained with p26 R114A was  500 kDa, closer to the mass of the WT oligomer than the other ... WHSP16.9, wheat Hsp16.9, 1GME. sHSP domains based on the sequence of p26 are indicated above the alignment, secondary structure elements based on the sequence of whea...

Ngày tải lên: 07/03/2014, 12:20

... Models of the potential interaction of decorin with type I a nd type VI co llagens. Decorin is shown by the grey arrow, the tip of the arrow represents the C-terminus; the dashed line indicates the ... fibril forming collagens are traversed specifically near their ÔdÕ bands, within the gap region of the collagen fibrils, by the filamentous beaded structures of t...

Ngày tải lên: 07/03/2014, 16:20