Báo cáo khoa học: MicroRNA-143 reduces viability and increases sensitivity to 5-ﬂuorouracil in HCT116 human colorectal cancer cells potx

... FEBSmiR-143 modulates 5-FU cytotoxicity P. M. Borralho et al. MicroRNA-143 reduces viability and increases sensitivity to 5-ﬂuorouracil in HCT116 human colorectal cancer cells Pedro M. Borralho1, ... apoptosis-inducing drug; indeed,it was shown previously that 5-FU induces apoptosis in HCT116 cells [20]. 5-FU has been used in the clinic forseveral decades, and its metabolic pathways and cyto-toxic ... proteins involved in the regulation of cell proliferation, death and chemotherapy response. In addition, miR-143 increases the sensitivity of colon cancer cells to 5-ﬂuorouracil, probably acting...

Báo cáo khoa học: Effects of the antioxidant PycnogenolÒ on cellular redox systems in U1285 human lung carcinoma cells docx

... detected using a chemilu-minescence Western Lightning kit (PerkinElmer, Boston,MA, USA) according to the manufacturer’s instructions.Real-time PCRTotal RNA was isolated using and RNeasy mini kit ... thiore-doxin family proteins are induced in several tumors, and the thioredoxin system is thus suggested to be aprime target in cancer therapy [24–26].The aim of this study was to investigate the antioxi-dant ... TrxR2 in themitochondria, which may be slightly less affected thanthe cytosol under these conditions. As TrxR is induced in various pathological conditions, including tumours and in ammatory...

Tài liệu Báo cáo khoa học: "AUTOMATIC SPEECH RECOGNITION AND ITS APPLICATION TO INFORMATION EXTRACTION" pdf

... on the readings of words in order to take into account the frequency and context-dependency of the readings. Broadcast news speech includes filled pauses at the beginning and in the middle ... to make the speech recognition systems robust against acoustic and lingustic variation in speech. In this context, a paradigm shitt from speech recognition to understanding where underlying ... domain of obvious value has lead to rapid technology transfer of speech recognition into other research areas and applications. Since the variations in speaking style and accent as well as in...

Báo cáo khoa học "ADIABATIC TEMPERATURE RISE AND REACTION RATE OF MASS STRUCTURE IN LOTTE CENTER HANOI PROJECT " pptx

... through finite analysis. As a result, a thermal crack index is over 1.0 and a curing time of mass-section foundation decreases within 18 days through minimizing binders in concrete and adjusting ... method such as pre-cooling and pipe-cooling and the other is to control material by adjusting binder to occurea low hydration temperature. And all the methods are essential to check analysis of ... bar, structure type. but internal restraining stress happen due to difference in temperature between inside and outside and temperature distribution curve is spreaded in the center of concrete...

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... glucosetransport in muscle and fat cells. To gain some insight intothis issue we subsequently monitored the effects of a numberof inhibitors that target PI3K, the MAP kinase pathway,p38 MAP kinase and mTOR ... nMinsulin alone or with 100 nMwortmannin for 15 min beforeexposing cells to insulin. Following these incubations cells were lysed and GSK3 a or b immunoprecipitated for analysis of kinase ... thebinding of insulin to its receptor and activation of thereceptor kinase, which tyrosine phosphorylates intracellulartarget substrates, in particular insulin receptor substrate 1(IRS-1) and its...

Báo cáo khoa học: Contributions of host and symbiont pigments to the coloration of reef corals pptx

... contribute to this coloration in a major way.They were initially discovered in nonbioluminescent,zooxanthellate anthozoa, including actiniaria, zoanth-aria, corallimorpharia and stolonifera [1–4], and ... green -to- redphotoconvertible ﬂuorescent proteins. The red ﬂuorescent proteins arelocalized mainly in the ectodermal tissue and contribute up to 7.0% of thetotal soluble cellular proteins in these ... studies, and therefore wehave analyzed in detail the origin of red ﬂuorescentcoloration of Faviina and Meandriina corals.Results and DiscussionGFP-like proteins contribute in a major way to the...

Báo cáo khoa học: Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni doc

... glycoproteins inclu-ding seminal plasma glycodelin [16], thyrotropin [17] and tissue factor pathway inhibitor [18], but are alsoexpressed by various pathogens, including the human parasite Schistosoma ... al.(2003) Dominant antibody responses to Fuc (alpha1–3)GalNAc and Fuc (alpha1–2) Fuc (alpha1–3) GlcNAccontaining carbohydrate epitopes in Pan troglodytesvaccinated and infected with Schistosoma ... was not detected. In conclusion, link-age analysis data were in line with the postulatedLDNF and diLDNF antennae (Figs 7 and 9).Furthermore, in order to obtain detailed informationabout the...

Báo cáo khoa học: "Using Large Monolingual and Bilingual Corpora to Improve Coordination Disambiguation" ppt

... meatasbestos and English: polyvinyl chloride and asbestos w2h and w1polyvinyl English: asbestos , and polyvinyl chloride w1, and w2hchloride English: asbestos and chloride w1 and h(no ... asbestos and polyvinyl chloride),or 2) The conjunction links something higher up in the parse tree, as in, “farmers are getting older\w1 and younger\w2people\h are reluctant to take upfarming.” ... Xiang-RuiWang, and Chih-Jen Lin. 2008. LIBLINEAR: A li-brary for large linear classiﬁcation. JMLR, 9:1871–1874.Victoria Fossum and Kevin Knight. 2008. Using bilin-gual Chinese-English word alignments to...

Báo cáo khoa học: "Using Lexical Dependency and Ontological Knowledge to Improve a Detailed Syntactic and Semantic Tagger of English" pot

... OOV’s. This is in line with our intuition, sincethese features rely on the identity of the word be-ing tagged, and the performance gain we see isdue to the improvement in labeling accuracy of ... isnot necessarily constrained to accept this choiceof syntax. Rather, it is able to decide both syn-tax and semantics while taking semantic contextinto account. In order to ﬁnd the most probablesequence ... practice. It is possible to eliminate features217which provide little or no beneﬁt to the model,thus speeding up the training. In some cases iteven allows a model to be trained where it wouldnot...

Báo cáo khoa học: Modulation of heme and myristate binding to human serum albumin by anti-HIV drugs An optical and NMR spectroscopic study potx

... abacavir (A) and nevirapine (B) binding to HSA (FA free), at pH 7.0 and 25°C.Fig. S2. Binding isotherms for Fe(III)heme binding to HSA (FA free) and to HSA–myristate complexes in the absence ... 2007)doi:10.1111/j.1742-4658.2007.05978.x Human serum albumin (HSA) has an extraordinary ligand-binding capac-ity, and transports Fe(III)heme and medium- and long-chain fatty acids. In human immunodeﬁciency virus-infected patients ... concomitant intoxication of thepatient [7,35,51]. Moreover, binding of drugs to FA2 reduces the afﬁnity of FA7 and increases the afﬁnityof FA1 ligands. Eventually, FA6 ligands are expected to affect in...

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