Báo cáo khoa học: MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells potx

... FEBS miR-143 modulates 5-FU cytotoxicity P. M. Borralho et al. MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells Pedro M. Borralho 1 , ... apoptosis-inducing drug; indeed, it was shown previously that 5-FU induces apoptosis in HCT116 cells [20]. 5-FU has been used in the clinic for several deca...

Ngày tải lên: 07/03/2014, 00:20

... detected using a chemilu- minescence Western Lightning kit (PerkinElmer, Boston, MA, USA) according to the manufacturer’s instructions. Real-time PCR Total RNA was isolated using and RNeasy mini kit ... thiore- doxin family proteins are induced in several tumors, and the thioredoxin system is thus suggested to be a prime target in cancer therapy [24–26]. The aim of this study wa...

Ngày tải lên: 30/03/2014, 02:20

... on the readings of words in order to take into account the frequency and context-dependency of the readings. Broadcast news speech includes filled pauses at the beginning and in the middle ... to make the speech recognition systems robust against acoustic and lingustic variation in speech. In this context, a paradigm shitt from speech recognition to understanding whe...

Ngày tải lên: 20/02/2014, 18:20

... through finite analysis. As a result, a thermal crack index is over 1.0 and a curing time of mass-section foundation decreases within 18 days through minimizing binders in concrete and adjusting ... method such as pre-cooling and pipe-cooling and the other is to control material by adjusting binder to occurea low hydration temperature. And all the methods are essential to...

Ngày tải lên: 07/03/2014, 03:20

... glucose transport in muscle and fat cells. To gain some insight into this issue we subsequently monitored the effects of a number of inhibitors that target PI3K, the MAP kinase pathway, p38 MAP kinase and mTOR ... n M insulin alone or with 100 n M wortmannin for 15 min before exposing cells to insulin. Following these incubations cells were lysed and GSK3 a or b immunoprecipi...

Ngày tải lên: 08/03/2014, 08:20

... contribute to this coloration in a major way. They were initially discovered in nonbioluminescent, zooxanthellate anthozoa, including actiniaria, zoanth- aria, corallimorpharia and stolonifera [1–4], and ... green -to- red photoconvertible fluorescent proteins. The red fluorescent proteins are localized mainly in the ectodermal tissue and contribute up to 7.0% of the total solub...

Ngày tải lên: 16/03/2014, 11:20

... glycoproteins inclu- ding seminal plasma glycodelin [16], thyrotropin [17] and tissue factor pathway inhibitor [18], but are also expressed by various pathogens, including the human parasite Schistosoma ... al. (2003) Dominant antibody responses to Fuc (alpha1–3) GalNAc and Fuc (alpha1–2) Fuc (alpha1–3) GlcNAc containing carbohydrate epitopes in Pan troglodytes vaccinated and infe...

Ngày tải lên: 16/03/2014, 14:20

... meat asbestos and English: polyvinyl chloride and asbestos w 2 h and w 1 polyvinyl English: asbestos , and polyvinyl chloride w 1 , and w 2 h chloride English: asbestos and chloride w 1 and h (no ... asbestos and polyvinyl chloride), or 2) The conjunction links something higher up in the parse tree, as in, “farmers are getting older\w 1 and younger\w 2 people\h are reluct...

Ngày tải lên: 17/03/2014, 00:20

... OOV’s. This is in line with our intuition, since these features rely on the identity of the word be- ing tagged, and the performance gain we see is due to the improvement in labeling accuracy of ... is not necessarily constrained to accept this choice of syntax. Rather, it is able to decide both syn- tax and semantics while taking semantic context into account. In order to fi...

Ngày tải lên: 17/03/2014, 04:20

... abacavir (A) and nevirapine (B) binding to HSA (FA free), at pH 7.0 and 25°C. Fig. S2. Binding isotherms for Fe(III)heme binding to HSA (FA free) and to HSA–myristate complexes in the absence ... 2007) doi:10.1111/j.1742-4658.2007.05978.x Human serum albumin (HSA) has an extraordinary ligand-binding capac- ity, and transports Fe(III)heme and medium- and long-chain fatty...

Ngày tải lên: 23/03/2014, 07:20