Báo cáo khoa học: The nucleosome-binding protein HMGN2 modulates global genome repair potx

... impairs DNA repair rate in chromatin FEBS Journal 276 (2009) 6646–6657 ª 2009 The Authors Journal compilation ª 2009 FEBS 6657 The nucleosome-binding protein HMGN2 modulates global genome repair Mangalam ... decrease in the CPD content of the DNA of all the cells, an indication of active repair of the damaged DNA. However, the removal of CPDs from the chromat...

Ngày tải lên: 07/03/2014, 00:20

... mixing together HIS-OXI1 and GST-PTI1-4 proteins or HIS-PTI1-4 and GST-OXI1 proteins, the GST-tagged proteins were pulled down with glutathi- one-agarose beads. The proteins were then detected ... pathogen attack. The Arabidopsis genome encodes 39 AGC kinases, of which 23 are classified to the AGC VIII group [8,9]. The AGC kinases were named on the basis of their homology to the...

Ngày tải lên: 14/02/2014, 19:20

... independent proteins and peptides leads to the disassembly of the spherical capsid inside the virion. Some of the folded domains of Gag are then able to reassemble as inde- pendent proteins. The matrix protein ... involved either in the assembly of the immature HIV-1 capsid, or in the reassembly of CA into a mature capsid. The detailed description of the structure and co...

Ngày tải lên: 18/02/2014, 06:20

... polyprotein, yields the matrix protein (MA), the capsid protein (CA), the nucleocapsid protein (NC) and p6 proteins, as well as two spacer pep- tides. Currently, most of the available drugs in the ... folding of both the CAI peptide and a-helix 9 of CTD during formation of the peptide– protein and protein protein complexes. These NMR experiments also allowed the dete...

Ngày tải lên: 18/02/2014, 06:20

... [10]. The curve fits to the data points for tadpole narcosis by the additional alcohols of Table 1 are shown in Fig. 2 along with the theoretical curves for the enhancement of agonist binding to the ... constant. The curves for the nAChR shown on the right were calculated as described in the Results. The following fitted curves to the data points (d)for tadpole narcosis...

Ngày tải lên: 19/02/2014, 18:20

... anti-T7) was then used to monitor the location of the epitope-tagged region with respect to the KdpD protein in the membrane. The KdpD protein with the epitope tags was readily digested by proteinase ... and was not digested by the protease. Taken together, these results suggest that the second periplasmic loop of the wild-type KdpD protein is inserted into the membr...

Ngày tải lên: 20/02/2014, 11:20

... humans. The RNA genome of the virus encodes a Gag polyprotein, which is further processed into matrix, capsid and nucleocapsid proteins. These proteins play a significant role at several steps in the ... 6118–6127 ª 2009 The Authors Journal compilation ª 2009 FEBS contains the viral RNA genome coated by the NC protein. The mature virion can then infect other host cells. Alon...

Ngày tải lên: 07/03/2014, 00:20

... demonstrating: (a) the inability of the mutant to insert a cofactor, and (b) the specific origin of the signal in the other samples. The cytosolic fraction of the complemented wild-type clearly showed the EPR ... between the total activity in the nonfractionated cell lysate and the sum of the individual fractions can be easily explained by either loss of material or pr...

Ngày tải lên: 07/03/2014, 11:20

... example and then used to generate a prediction for the left- out example. The meta-classifier is trained using the predictions of the base-level classifiers as features, and the true label as given by the ... Under these re- strictions, RE became an instance of entity labeling, where the label assigned to an entity (e.g. Father) is its relation to the topic of the article. Oth...

Ngày tải lên: 08/03/2014, 01:20

... brain. The solubilization of the ICD of RNF13 and the presence of the putative NLS on the C-terminal side of the TM domain are consistent with the possibility that the ICD, released from the mem- brane ... suggesting that the N-terminal portion of the protein containing the HA epitope was lost from these proteins by pro- teolysis. To determine which of the RNF13 ba...

Ngày tải lên: 18/02/2014, 08:20