Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

... (2009) 6204–6217 ª 2009 The Authors Journal compilation ª 2009 FEBS 6217 Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability Ewa Przybytkowski, ... NPs can affect the intracellular metabolism of lipids and induce HIF-1a-mediated signaling. The results suggest that QDs, together with tr...

Ngày tải lên: 07/03/2014, 00:20

... provide information on the local repartition of the angles involved in the SRE fos helix bending. Relative effect of bending strain There are several indications of a redistribution of the strains ... Indeed, the change in the array of the hydrogen bonds at thymine of SRE GGfos is probably a sign of perturbation in the hydration scheme along the minor gro...

Ngày tải lên: 07/03/2014, 09:20

... 7. KCNE trafficking in the presence of KCNQ1, and KCNQ1 trafficking in the presence of multiple KCNE proteins. Representa- tive western blots examining KCNE protein trafficking to the plasma membrane ... 6), indicating that impaired KCNQ1 cell surface expression cannot explain the suppression of I Ks by KCNE4. Next, we examined the ability of KCNE proteins to traffic to the...

Ngày tải lên: 18/02/2014, 17:20

... biological activity of MIH and CHH during precisely timed stages of the moult cycle of Carcinus to determine changes in: (a) potency of these peptides in repressing ecdysteroid synthesis; (b) receptor ... level. In view of these observations, we also investigated levels of MIH and CHH peptides in the sinus gland and levels of transcripts in XO neurones during the...

Ngày tải lên: 21/02/2014, 00:20

... allows the estimation of the effect of intracellular binding on the MDR phenomenon. The data detailed obtained in the present study indicate that innate cellular MDR interferes successfully with the ... of rhodamine dyes into cells is to follow their quenching upon entering the cells. In respiring cells, the active concentration of these dyes in the mitocho...

Ngày tải lên: 18/02/2014, 13:20

... address the in uence of the reaction conditions on the binding of Fpg and OGG1 to damaged DNA, we determined K d values for binding under the same conditions as used for the kinetic experi- ments. In ... Polyamines, crowding agents, biotin and caffeine affected the activity and specificity of Fpg or OGG1 only marginally. We conclude that, in the intracellular environ...

Ngày tải lên: 18/02/2014, 18:20

... domain deletions are more com- mon at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein and the ... C−terminus Length of the N terminus in % of the deleted domain Length of the C terminus in % of the deleted domain Pfam, N−terminus Pfam, C −terminus Number...

Ngày tải lên: 19/02/2014, 07:20

... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... substrates. The lack of inhibition observed with benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine (Fig. 5B) suggests differences in binding of...

Ngày tải lên: 19/02/2014, 07:20

... Another way of classifying ap- proaches is based on the learning aspect during the construction of the morphological model. If the data for training the model has the same struc- ture as the ... cross- validation on datasets ranging from 500 to 2500 words with the goal of measuring how the learning improves with increasing experience in terms of training set size....

Ngày tải lên: 20/02/2014, 04:20

... testing and the rest of the data for training. Table 7 summarizes the performance of our classifier with the different feature sets in this classification task, distinguishing the case where the four ... other speaker seconds of silence during the spurt speech rate in the spurt Lexical features: number of words in the spurt number of content words in the sp...

Ngày tải lên: 20/02/2014, 16:20