Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: interactions of HIV-1 capsid with host protein factors ppt

... of HIV-1 capsid FEBS Journal 276 (2009) 6118–6127 ª 2009 The Authors Journal compilation ª 2009 FEBS 6127MINIREVIEW The capsid protein of human immunodeﬁciency virus: interactions of HIV-1 capsid ... 2009)doi:10.1111/j.1742-4658.2009.07315.x HIV-1 is a retrovirus that causes AIDS in humans. The RNA genome of the virus encodes a Gag polyprotein, which is further processed intomatrix, capsid and nucleocapsid proteins. These proteins ... cofactors within the infected host cell. This minireview focuses on the proteomics of the capsid protein, its inﬂuence on the packaging of nonviral molecules into HIV-1 virions and the subsequent...

Báo cáo khoa học: The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases pdf

... but not with the D105G variant of rMASP-2 and the Y59A variant of rMAp19, is consis-tent with the fact that the variants lack the ability toassociate with rMBL [56,57]. In the same way, the factthat ... [24–31]. These affect the oligomer-ization of the protein, indirectly affecting the associa-tion with the MASPs, or directly affecting the bindingsite for the MASPs, which has been localized to the C-terminal ... site of the N-domain not involved in the interaction with C1qand the collectins. The physiological relevance of the interaction of cal-reticulin with MBL and C1q cannot be deduced from the results...

Báo cáo khoa học: The gp130⁄STAT3 signaling pathway mediates b-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes ppt

... stimulation, at either 1 h or 3 h (supple-mentary Fig. S1). As qRT-PCR could not exclude the possibility of release of pre-existing IL-6, we furthermonitored the secretion of IL-6 protein by ELISA.ISO ... could not increase IL-6 protein production ascompared with control within 3 h in the medium of cultured cardiomyocytes (supplementary Fig. S2).Therefore, there may be some other, as yet unidenti-ﬁed, ... 4C). The involvement of STAT3 in b-AR-induced ANFexpression was further supported by investigation of the instant upstream signaling of STAT3, in that bothinhibition of gp130 and inhibition of...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: intersubunit interactions during virus assembly doc

... independentproteins and peptides leads to the disassembly of the spherical capsid inside the virion. Some of the foldeddomains of Gag are then able to reassemble as inde-pendent proteins. The matrix protein ... diverse CA–CA interactions and inter-faces involved either in the assembly of the immature HIV-1 capsid, or in the reassembly of CA into amature capsid. The detailed description of the structureand ... energeticcharacterization of CA–CA interfacesin the mature HIV-1 capsid From the results reviewed above, it could be concludedthat the picture of CA–CA and other protein protein interfaces in the immature HIV-1 capsid...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: designing inhibitors of capsid assembly ppt

... 2009)doi:10.1111/j.1742-4658.2009.07314.x The mature capsid of human immunodeﬁciency virus, HIV-1, is formed by the assembly of copies of a capsid protein (CA). The C-terminal domain of CA, CTD, is able to homodimerize and most of the ... Mascarenhas AP & Karin Musier-Forsyth K (2009) The capsid protein of human immunodeﬁciency virus: interactions of HIV-1 capsid with host protein factors. FEBS J 276, doi:10.1111/j.1742-4658.2009.07315.x.8 ... on the capsid protein of the human immunodeﬁciency virustype 1: a new drug target? Sci World J 9, 404–419.6 Mateu MG (2009) The capsid protein of human immu-nodeﬁciency virus: intersubunit interactions...

Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx

... forms of the MAPKs were produced as GST-lofMPK3 and GST-lofMPK6. However, when lofMPK3 and lofMPK6proteins were tested for phosphorylation with OXI1,no phosphorylation of lofMPK3 or lofMPK6 ... mixed with GST alone as acontrol or with GST-tagged proteins. (B) The HIS-PTI1-4 protein was mixed with GST alone as a control or with GST-tagged proteins. In (A)and (B), the GST-tagged proteins ... PTI1-4, another member of the PTI1-like family, interacts with OXI1. By using yeasttwo-hybrid assays, other members of the AGC family(AGC2-2 and AGC2-3) were shown to interact with the PTI1-4...

Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc

... [10].Although the occurrence of family 33 CBPs has beenknown for some time [23], the present results provideonly the third demonstration of the accessory function of these proteins. The effect of LlCBP33A ... drawnfor ChiC1 from S. marcescens. The fact that the longerpart of the substrate extends towards the + side of the catalytic centre is compatible with the notion that the C-terminal substrate-binding ... intervals. The degradation of a-chitin by LlChi18A started with a rapid phase, regardless of the presence of LlCBP33A. In the presence of LlCBP33A, the fastinitial phase was maintained longer than in the...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is inde-pendent and different from that of the chaperone). The standard errors associated with this theoretical ... (seebelow). The effect of the additives on aggregation of the target protein (in the absence and presence of aB-crystallin)was assessed at the end of each assay by calculating the percentage ... calculated from the standard errorsassociated with the means of the measured values (i.e. bycalculating the square root of the sum of the associatedindividual errors squared). The maximum percentage...

Tài liệu Báo cáo khoa học: The elusive intermediate on the folding pathway of the prion protein pptx

... represents the co-operativity of the transition, and [D]50%is the concentration of urea at the midpoint of unfolding, i.e. the concentration of urea required to denature 50% of the protein. Intersection ... [33,34].DiscussionAccording to the prion hypothesis, a key molecularevent in the pathogenesis of prion diseases is the conversion of the normal cellular form of the prion protein, PrPC, to the disease-associated ... indicative of the existence of stable, partially folded intermediateson the folding pathway of a protein [27–30]. The presence of an intermediate on the folding path-way of PrP was further disclosed...

Tài liệu Báo cáo khoa học: The most C-terminal tri-glycine segment within the polyglycine stretch of the pea Toc75 transit peptide plays a critical role for targeting the protein to the chloroplast outer envelope membrane ppt

... 17% of residues within this stretch.We replaced the critical tri-glycine within the peaToc75 transit peptide with repeats of these threeFig. 3. Time course of the distribution of imported proteins. ... speciﬁcity in vitro.Replacement of the most C-terminal segment with alanine residues resultedin mistargeting the protein to the stroma, while exchange of either of the other two tri-glycine regions ... 4B,C). Import of GGE mutant was less efﬁcientthan that of other proteins, as evidenced by the accumu-lation of the precursor form of Toc75 that was sensitiveto thermolysin after the import (Fig....

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