Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc

... SG, Park BC, Kim G-H & Rhee S (2006) Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Proc Nat Acad Sci ... P (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-causing aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78, 6858–6862. The evol...

Ngày tải lên: 07/03/2014, 00:20

... in transthyretin genes from fish to amphibian, to reptilian and avian, to marsupial and, finally, to eutherian species [15,16,38–40]. P. Prapunpoj and L. Leelawatwattana Structure function relationships ... sea bream [45]; carp (accession number CAD66520); and sea lamprey and American brook lamprey [40]. (Modified from Prapunpoj et al., 2002 [16].) P. Prapunpoj and L. Leela...

Ngày tải lên: 07/03/2014, 00:20

... Identification of transthyretin in fish (Sparus aurata): cDNA cloning and characterisation. Endocrinology 140, 2430–2433. 61 Yamauchi K, Nakajima J, Hayashi H & Hara A (1999) Purification and characterization ... common ancestor of eutherians and marsupials is presumably more closely related to American marsupials than to Australian marsupials or to eutherians, this suggest...

Ngày tải lên: 07/03/2014, 00:20

... of pro-death proteins, such as cytochrome c, which are released into the cytoplasm as a consequence of apoptotic signals. The release of these apoptotic factors involves alteration of the mitochondrial ... total helical structure, considering both regular and distorted a- helix, are calculated in the case of Bax -a5 and % 20% in the case of Bax -a6 (Table 1). The presence...

Ngày tải lên: 19/02/2014, 07:20

... needs to have access to at least rhetorical and document information as well as referencing and adding to the syntactic information. To accommodate this, the RAGS data model in- cludes a more ... (a 2-tuple), DocAttr (a set of DocFeatAtoms – feature-value pairs), DocRe- pSeq (a sequence of DocReps or DocLeafs) and DocLeafs. The active database server supports multiple i...

Ngày tải lên: 31/03/2014, 04:20

... structures are highly variable, with the invariant parts comprising mainly the b-strands. The loops between strands B and C, known as the ‘hypervariable loop‘, D and E, E and F, F and G, and G and H are ... Mullen GP, Abeygunawardana C, Lattman EE & Mildvan AS (1992) NMR docking of a substrate into the X-ray structure of staphylococcal nuclease. Proteins 13, 275–287. 5...

Ngày tải lên: 15/03/2014, 23:20

... suggestive of partial tetramerization (Fig. S1). Chemical stability of holo and apo S10 0A2 proteins The conformational stability of S10 0A2 -wt and mutants, in the apo and distinct metallated states, was investigated ... °C using far-UV CD (Fig. 1). The CD spectra of all protein preparations are typical of a- helix proteins, with local minima at 208 and 222 nm and loc...

Ngày tải lên: 30/03/2014, 02:20

... far-UV CD spectra. Calcium aliquots were added from a standard stock solution to a final con- centration of 0, 0.1, 1 and 10 m M to bB2-crystallin and 0, 0.5, 1 and 5 m M to bA3-crystallin. A B Fig. ... ML, Rao SC, Somasunda- ram T, Gopalakrishna A & Balasubramanian D (1989) Calcium ion binding to d- and to b-crystallins. Presence of EF-hand motif in d-crystal...

Ngày tải lên: 18/02/2014, 16:20

... is common to the proposals of Dowty, Reape, and Kathol, and to the particular analysis implemented here, is the characterization of nat- ural language syntax in terms of two interrelated but ... hierarchical structure. To this end, we follow Reape and Kathol and utilize order domains, which are associated with each node of the hierarchical structure, and serve...

Ngày tải lên: 20/02/2014, 18:20

... uses a static list of manually-defined rules linking category pairs and semantic relations, while our PRO algorithm au- tomatically and dynamically computes links be- tween sense pairs and relations ... that compound by hand, and seeing if that re- lation was the same across all compounds under that category pair. If that relation was the same across all selected compounds, that ca...

Ngày tải lên: 08/03/2014, 02:21