Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc

... SG, Park BC, Kim G-H &Rhee S (2006) Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Proc NatAcad Sci ... P(1981) Uric acid provides an antioxidant defense inhumans against oxidant- and radical-causing aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78,6858–6862.The evolution of the transthyretin-like ... 0Loktanella vestfoldensis SKA53 Proteobacteria, Alphaproteobacteria 2 0Roseovarius sp. HTCC2601 Proteobacteria, Alphaproteobacteria 2 0Ralstonia eutropha H16 Proteobacteria, Betaproteobacteria...

Báo cáo khoa học: Evolutionary changes to transthyretin: structure–function relationships ppt

... in transthyretin genes from ﬁsh to amphibian, to reptilian and avian, to marsupial and, ﬁnally, to eutherian species [15,16,38–40].P. Prapunpoj and L. Leelawatwattana Structure function relationships ... sea bream [45]; carp (accession number CAD66520); and sealamprey and American brook lamprey [40]. (Modiﬁed from Prapunpoj et al., 2002 [16].)P. Prapunpoj and L. Leelawatwattana Structure function ... Several cleavage sites (e.g. aftertyrosine and phenylalanine; after lysine; and after ala-nine) were identiﬁed. Transthyretin cleaved both thesoluble and the aggregated forms of Ab, and the Abamyloidogenicity...

Báo cáo khoa học: Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis doc

... Identiﬁcation of transthyretin in ﬁsh (Sparus aurata): cDNA cloning and characterisation. Endocrinology 140, 2430–2433.61 Yamauchi K, Nakajima J, Hayashi H & Hara A (1999) Puriﬁcation and characterization ... common ancestor of eutherians and marsupials is presumably more closely related to American marsupials than to Australian marsupialsor to eutherians, this suggests that (at least in mam-mals) as ... within the Class Amphibia:Anura (frogs and toads), Urodela (newts and salaman-ders) and Gymnophiona (caecilians). Of these, only a few species of Anura have been investigated regardingtransthyretin...

Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf

... of pro-death proteins, such as cytochrome c,which are released into the cytoplasm as a consequence of apoptotic signals. The release of these apoptoticfactors involves alteration of the mitochondrial ... total helical structure, considering both regular and distorted a- helix, arecalculated in the case of Bax -a5 and % 20% in the case of Bax -a6 (Table 1). The presence of even moderateamounts of ... helices 5 and 6 of Bax canindependently form large lipid poresAna J. Garcı a- Sa´ez1, Manuela Coraiola3, Mauro Dalla Serra3, Ismael Mingarro1, Peter Mu¨ller4 and Jesu´s Salgado1,21...

Báo cáo khoa học: "From RAGS to RICHES: exploiting the potential of a ﬂexible generation architecture" pot

... needs to have access to at least rhetorical and document information as well as referencing and adding to the syntactic information. To accommodate this, the RAGS data model in-cludes a more ... (a 2-tuple), DocAttr (a set of DocFeatAtoms – feature-value pairs), DocRe-pSeq (a sequence of DocReps or DocLeafs) and DocLeafs.The active database server supports multipleindependent O /A ... representation is a simpletyped network representation language. An O /A database consists of a collection of objects, each of which has a unique identiﬁer and a type, and arrows, each of which has a unique...

Báo cáo khoa học: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology docx

... structures are highlyvariable, with the invariant parts comprising mainly theb-strands. The loops between strands B and C, knownas the ‘hypervariable loop‘, D and E, E and F, F and G, and G and H are ... Mullen GP, AbeygunawardanaC, Lattman EE & Mildvan AS (1992) NMR docking of a substrate into the X-ray structure of staphylococcalnuclease. Proteins 13, 275–287.50 Arlaud GJ, Gagnon J, Villiers ... subunit, a modular serineprotease. In an extraordinary example of ‘action at a distance’, an activation signal is then mechanicallytransmitted to two molecules of C1r that are locatedwithin...

Báo cáo khoa học: Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 docx

... suggestive of partial tetramerization(Fig. S1).Chemical stability of holo and apo S10 0A2 proteinsThe conformational stability of S10 0A2 -wt and mutants, in the apo and distinct metallated states, wasinvestigated ... °C using far-UV CD (Fig. 1). The CDspectra of all protein preparations are typical of a- helix proteins, with local minima at 208 and 222 nm and local maxima at 195 and 215 nm, in agreementwith ... different metallation states (apo, Zn2+ and Ca2+)was performed. Thermal denaturation experiments showed that Zn2+actsas a destabilizer and Ca2+as a stabilizer of the protein conformation....

Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx

... far-UV CD spectra. Calciumaliquots were added from a standard stock solution to a ﬁnal con-centration of 0, 0.1, 1 and 10 mM to bB2-crystallin and 0, 0.5, 1 and 5 mM to bA3-crystallin. A BFig. ... ML, Rao SC, Somasunda-ram T, Gopalakrishna A & Balasubramanian D (1989)Calcium ion binding to d- and to b-crystallins. Presence of EF-hand motif in d-crystallin that aids in calciumbinding. ... results haveimportant implications for understanding the calcium-related cataracto-genesis and maintenance of ionic homeostasis in the lens.AbbreviationsAIM1, protein absent in melanoma 1; HSQC,...

Tài liệu Báo cáo khoa học: "Know When to Hold''''Em: Shuffling Deterministically in a Parser for Non concatenative Grammars*" pdf

... is common to the proposals of Dowty, Reape, and Kathol, and to the particular analysis implemented here, is the characterization of nat- ural language syntax in terms of two interrelated but ... hierarchical structure. To this end, we follow Reape and Kathol and utilize order domains, which are associated with each node of the hierarchical structure, and serve as the domain of application ... perfor- mance of the optimized and non-optimized parsers. 2 A German Grammar Fragment The fragment is based on the analysis of German in Kathol's (1995) dissertation. Kathol's approach...

Báo cáo khoa học: "Using WordNet to Automatically Deduce Relations between Words in Noun-Noun Compounds" docx

... uses a static list of manually-deﬁned rules linking category pairs and semantic relations, while our PRO algorithm au-tomatically and dynamically computes links be-tween sense pairs and relations ... that compound by hand, and seeing if that re-lation was the same across all compounds underthat category pair. If that relation was the sameacross all selected compounds, that category pairwas ... everyday language and are especiallyfrequent, and important, in technical documents(Justeson & Katz, 1995, report that such phrasesform the majority of technical content of scien-tiﬁc and...

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