Báo cáo khoa học: Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis doc

... mechanism of the N-terminus and the influences of this change on binding to TH and on the functions of transthyretin, including that of proteolysis. Structure of transthyretin 3D structure of human transthyretin The ... probably because transthyretin is part of a network with other thyroid hormone dis- tributor proteins. Systematic study of the evolutionary changes...

Ngày tải lên: 07/03/2014, 00:20

... Journal compilation ª 2009 FEBS MINIREVIEW Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis Samantha J. Richardson School of Medical Sciences, RMIT University, Bundoora, ... regulation of transthyretin gene expression throughout evolution required the evolution of sophisticated families of tran- scription factors, co-modulator prote...

Ngày tải lên: 07/03/2014, 00:20

... compilation ª 2009 FEBS 5379 MINIREVIEW Evolutionary changes to transthyretin: structure and function of a transthyretin- like ancestral protein Sarah C. Hennebry Department of Biochemistry and Molecular ... structure of the thyroid hormone distributor protein, transthyretin, has been highly conserved during the evolution of vertebrates. Over the last decade, studies into...

Ngày tải lên: 07/03/2014, 00:20

... methionine) were allowed to react over a time range of 10 min to 12 h with hydroxy radical and other reactive oxygen species. In these timescales, up to five oxygen atoms were incorporated into WT and V30M ... timescale range of 10 min to 12 h. Oxidation of WT and V30M TTR proteins in these timescales increased their molecular masses by 80 Da, indicating that up to five oxygen a...

Ngày tải lên: 19/02/2014, 05:20

... alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes CYC1 and CYC7, ... exposure of lung macrophages and rat L8 myocytes to 96 h of mild hypoxia (15–20 Torr) might be related to such a coordinated down regulation of mitochondrial and nuclea...

Ngày tải lên: 20/02/2014, 23:20

... define a link token to be an ordered pair of word tokens, one from each half of the bitext. A link type is an ordered pair of word types. Let n(u.,,) be the co-occurrence frequency of u and v ... classifies each word token, for example using a part -of- speech tagger, instead of assigning the same class to all tokens of a given type. The bitext pre- processor for our wo...

Ngày tải lên: 22/02/2014, 03:20

... )148 to )124 region of c-jun in the presence of much higher excess of fragmented calf thymus DNA to inspect the specificity of the interac- tions between RLjunRP and the )148 to )124 region of c-jun. ... under- taken to develop an understanding of regulation of c-jun expression in quiescent rat liver. We have identified a positive regulatory factor from normal rat liver th...

Ngày tải lên: 23/03/2014, 20:22

... various changes in the course of mito- chondrial origin are believed to represent the very first stage of a global evolutionary event, the conversion of an amito- chondriate pro-eukaryote into a ... F.,Lichtle,C.,Apt,K.,Martin,W.&Cerff,R.(2000) Compartment-specific isoforms of TPI and GAPDH are imported into diatom mitochondria as a fusion protein: evidence in favor of a mito...

Ngày tải lên: 31/03/2014, 01:20

... sequence of pushdowns, the stacks are piled up from left to right. II stands for the bottom of a stack, s~ is the top element of the top stack, Sx is the bottom element of the top stack, ... EPDA is similar to a pushdown automaton (PDA) except that the storage of an EPDA is a sequence of pushdown stores. A move of an EPDA (see Figure 1) allows for the introduction of...

Ngày tải lên: 31/03/2014, 18:20

... dynamic evolutionary history of b and c crystallins is part of the remarkably varied history of molecular modification of the lens in ter- restrial vertebrates through the direct gene recruit- ment of ... associated with photoreceptor disc shedding [48]. In evolution, functional retinas preceded the evolution of a focusing lens [3,49]. The proteins of the lens arose by the...

Ngày tải lên: 19/02/2014, 17:20