Báo cáo khoa học: Evolutionary changes to transthyretin: structure–function relationships ppt

... relationships of transthyretin FEBS Journal 276 (2009) 5330–5341 ª 2009 The Authors Journal compilation ª 2009 FEBS 5341 MINIREVIEW Evolutionary changes to transthyretin: structure–function relationships P. ... Langerhans, stored in the secretory granules and released upon exocytosis [81]. It is also a compo- nent in normal pancreatic b-cell stimulus-secretory cou- pling and act...

Ngày tải lên: 07/03/2014, 00:20

... – first to hydrolyse 5-HIU and second to decarboxylate OHCU to (S)-allantoin. As previously discussed, bacterial TLP genes are fre- quently found in close proximity to the uricase gene and to another ... thaliana TLP was reported to be localized only in the cytosol and was unlikely to have a function in pur- ine metabolism. In this study, the authors failed to take into account...

Ngày tải lên: 07/03/2014, 00:20

... endocrine disruptors. Furthermore, these endocrine disruptors can be transported into the brain via binding to transthyretin synthesized by the choroid plexus and have the potential to accumulate ... epithelium have been proposed to be involved in the delivery of retinol to Mu ¨ ller and amacrine cells [52], where it is converted to retinal, which is required for photoreceptor funct...

Ngày tải lên: 07/03/2014, 00:20

... leading to mixtures of modified pro- teins that may differ in function. In order to fully dis- sect the biological role of PTMs and determine precise structure–activity relationships, access to pure ... common to organic synthesis but not yet amenable to protein modification. As new methodologies emerge, the study of other PTMs and that of regulatory PTMs will hope- fully provide a p...

Ngày tải lên: 18/02/2014, 17:20

... the theory to be put into practice, there remain two important questions to be answered :- • I-low to produce surface strings from a set of sentences to be conjoined? • tlow to produce ... discussed in relation to the MSG implementation. Finally we can show how the simplifled device can l)e extended to deal with the issues of extending the sys- tem to handle n...

Ngày tải lên: 31/03/2014, 17:20

... histone methyltransferase. EMBO J 25, 4503–4512. 23 De Guzman RN, Goto NK, Dyson HJ & Wright PE (2006) Structural basis for cooperative transcription factor binding to the CBP coactivator. ... On the top, from left to right is the CXXC domain (PDB code: 2j2s) and the C-terminal SET domain (PDB code: 2w5z). On the bottom, from left to right is the MLL1 TAD domain (green) bound to t...

Ngày tải lên: 16/02/2014, 14:20

... °Cfor10hinaBeckmanSW28rotor. 1.2 mL fractions were collected from the top of the gradient and processed to analyze acid insoluble radioactivity. DNA cytofluorometry For cytofluorometry of cellular ... indicated incubations were stopped, cells were fixed with acetone/methanol and total DNA was stained with bisbenzimide. Subsequently cells were photographed and counted. The percentage of mitotic...

Ngày tải lên: 21/02/2014, 00:20

... 653 Introduction Diphtheria toxin is a protein secreted by Corynebacte- rium diphtheriae as a single polypeptide chain of 58 kDa [1]. During cell intoxication, diphtheria toxin is cleaved by furin into two fragments: ... binding to its cell-surface receptor, diphtheria toxin is internalized through the clathrin-coated pathway. The acidic pH in the endo- some triggers a conformational change...

Ngày tải lên: 16/02/2014, 09:20

... its ability to bind a wide range of protein cofactors [2]. Some bind directly to VCP in a mutually exclusive manner, targeting VCP to a particu- lar function. For example, binding to the ubiquitin Keywords endoplasmic ... their abil- ity to pull down VCP. Each peptide is fused to pGEX vector-encoded amino acids at both the N-terminus and C-terminus. Right: western blot (top) and S...

Ngày tải lên: 18/02/2014, 13:20

... HCT116 cells to proteasome inhibitors. Int J Oncol 24, 935–941. 19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratory gases of synovial fluids. An approach to synovial tissue circulatory–metabolic ... [2,3]. Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) are type II transmembrane mole- cules that trigger the apoptotic signal cascade by bind- ing to cognate recept...

Ngày tải lên: 18/02/2014, 14:20